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Multi-organ on a chip for personalized precision medicine

Published online by Cambridge University Press:  13 August 2018

Vivekanandan Palaninathan
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Vimal Kumar
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Toru Maekawa
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Dorian Liepmann
Department of Bioengineering, University of California, Berkeley, CA, USA
Ramasamy Paulmurugan
Department of Radiology, Cellular Pathway Imaging Laboratory, Stanford University School of Medicine, 3155 Porter Drive, Suite 2236, Palo Alto, CA 94304, USA
Jairam R. Eswara
Brigham and Women's Hospital, Division of Urology, 75 Francis Street, Boston, Massachusetts 02115, USA
Pulickel M. Ajayan
Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA
Shine Augustine
Department of Biotechnology, Delhi Technological University, Main Bawana Road, Delhi 110042, India
Bansi D. Malhotra
Department of Biotechnology, Delhi Technological University, Main Bawana Road, Delhi 110042, India
Sowmya Viswanathan
Newton-Wellesley Hospital, Newton, MA 02462, USA
Venkatesan Renugopalakrishnan*
Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
D. Sakthi Kumar*
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Address all correspondence to D. Sakthi Kumar and V. Renugoplakrishnan at and
Address all correspondence to D. Sakthi Kumar and V. Renugoplakrishnan at and
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The inefficiencies of the current pipeline from discovery to clinical approval of drugs demand a surrogate method to indicate adverse drug reactions, e.g. liver damage. Organ-on-chip (OOC) models would be an ideal, rapid, and human-specific alternate, which would render animal testing obsolete. The ground-breaking ability of OOCs and Multi-OOC constructs is the accurate simulation of the in vivo conditions of human organs leading to precise drug screens for cytotoxicity and/or drug efficacy at a faster pace and lesser cost. Here we discuss the innovation, architecture, and the progress of OOCs towards human body-on-a-chip.

2D Nanomaterials for Healthcare and Lab-on-a-Chip Devices Prospective Articles
Copyright © Materials Research Society 2018 

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This paper is dedicated to Suraj Renugopalakrishnan.


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