The majority of human pathogens cause disease in a biofilm lifestyle. Biofilms are communities of cells that remain attached to a foreign surface and to each other. The organisms secrete and become embedded in an extracellular polysaccharide matrix. Biofilm infections occur most commonly on implanted medical devices and are quite recalcitrant to antimicrobial therapy. The most common device involved in these infections is the intravenous catheter. More than 5 million intravenous catheters are inserted into patients in the United States annually of which up to 10% become infected with biofilm producing pathogens.