We have witnessed a slow but steady decline in electron microscopy (EM) skills in the biological sciences over the last decade. This decline is illustrated by the continued closures of EM facilities throughout the world. It is, however, difficult to rationalize this decline when the need for these skills is still under a constant demand. Certainly, the introduction of new microscopes has played a part in this. High-resolution confocal light microscopes, two photon imaging and other new technologies are providing impressive amounts of new information on biological systems. Many of these approaches require simple preparation protocols providing information that can be easily interpreted and are thus easily adapted to fast-moving research.

The application of EM techniques is also deceivingly simple. For this reason the field of immunocytochemistry is undergoing an increase in popularity. Laboratories with little or no previous experience in EM are discovering the impressive and convincing results achievable using these high-resolution methods.