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Skeletal Muscle Ultrastructural Pathology In Multihormonal Disorder

Published online by Cambridge University Press:  02 July 2020

A. Márquez ,
H.J. Finol ,
M. Pulido-Méndez  and
M. Campos de Veitía
A. Márquez
Affiliation:
Institute of Experimental Medicine, Medicine Faculty, Central University of Venezuela, Apartado, 47114, Caracas, 1041A, Venezuela
H.J. Finol
Affiliation:
Center for Electron Microscopy, Sciences Faculty, Central University of Venezuela.
M. Pulido-Méndez
Affiliation:
Institute of Experimental Medicine, Medicine Faculty, Central University of Venezuela, Apartado, 47114, Caracas, 1041A, Venezuela
M. Campos de Veitía
Affiliation:
Endocrine Unit, Caracas University Hospital, Caracas, Venezuela.
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Extract

Several endocrine disorders with increase or deficiency of hormone production may present a skeletal muscle compromise. Those conditions have been considered as metabolic myopathies. Nevertheless, some pathological abnormalities, mainly microvascular changes and the existence of a cell infiltrate, found in endocrine disorders with an autoimmune origin (primary hipothyroidism, hyperthyroidism associated with Graves disease, diabetes mellitus) have permitted classifing them as inflammatory myopathies. Although muscle pathology in diseases with isolated hormone production alteration has been extensively studied, this investigation has not been realized in patients with abnormalities in several endocrine glands. In this work we report the skeletal muscle ultrastructural pathology in a patient with multihormonal disorder.

A 19 years old male patient presented dwarfism with lack of muscular and sexual development. Plasma levels of thyroxin, Cortisol, growth hormone, testosterone, LH and FSH were low . TSH plasma levels were high.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1164 - 1165
Copyright
Copyright © Microscopy Society of America

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References

1. Finol, H.J. et al., Acta NeuropathoL, 71(1986)64.CrossRefGoogle Scholar

2. Márquez, A. et al., Acta Cient. Venez., 40(1989)251.Google Scholar

3. Márquez, A. et al., Proc. Int. Cong. Elect. Microsc, 1 (1994)1147.Google Scholar

4. Supported by grants from the CDCH of UCV (Nr. 03-10-4169-98) and CIFMUCVGoogle Scholar