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Evaluating Structural Differences in Cortical Bone Tissue After Demineralization and Calcination

Published online by Cambridge University Press:  03 October 2008

Gabriela Martins
Affiliation:
Departamento de Engenharia Mecânica, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Polo II da Universidade de Coimbra, Rua Luis Reis Santos, 3030-788 Coimbra, Portugal
João Freitas
Affiliation:
Serviço de Ortopedia, Hospitais da Universidade de Coimbra, Pct Mota Pinto, 3000-075 Coimbra
Fernando Judas
Affiliation:
Serviço de Ortopedia, Hospitais da Universidade de Coimbra, Pct Mota Pinto, 3000-075 Coimbra
Bruno Trindade
Affiliation:
Departamento de Engenharia Mecânica, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Polo II da Universidade de Coimbra, Rua Luis Reis Santos, 3030-788 Coimbra, Portugal
Helena Figueiredo
Affiliation:
Instituto de Histologia, Faculdade de Medicina da Universidade de Coimbra, 3004-504 Coimbra

Abstract

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Although the best results in bone grafting have been achieved with autogeneuos bone tissue, allografts and xenografts have been widely used either in mineralized, demineralized, or calcined forms. Demineralized bone has been proven to stimulate new bone formation by exposing, proteins and growth factors necessary for osteoinduction. On the other hand, calcined bone offers a natural architectural mineralized matrix, not present in synthetic apatite materials, as well as an excellent source of calcium. Despite the extensive use and importance of these materials, systematic works regarding their characterization are relatively scarce.

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Abstract
Copyright
Copyright © Microscopy Society of America 2008