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Correlative Neutron Activation and TEM to Determine the Uptake Mechanism and Distribution of Orally Administered Colloidal Gold Nanoparticles

Published online by Cambridge University Press:  02 July 2020

J.F. Hillyer  and
R.M. Albrecht
J.F. Hillyer
Affiliation:
Dept. of Animal Health & Biomedical Sciences, U. of Wisconsin - Madison, Madison, WI53706
R.M. Albrecht
Affiliation:
Dept. of Animal Health & Biomedical Sciences, U. of Wisconsin - Madison, Madison, WI53706
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Extract

The uptake of insoluble, particulate matter through the digestive tract occurs in low quantities, and the pathway and amount of particle uptake is size dependent. Previous studies have shown that the uptake of nanoparticles occurs mainly through the Peyer's patch regions of the small intestine while micrometer sized particles enter the body by a process called persorption: the paracellular uptake of microparticles from the digestive tract into the body. These studies have also shown that translocation is largely dependent on particle size: smaller particles are more readily absorbed. Research on the use of microparticles for the oral delivery of drugs, vaccines, and DNA have shown that protein, polysaccharide, and DNA microparticle encapsulation can increase uptake and bioavailability of absorbed molecules. All of these studies have used particles with diameters ranging from 0.1 to 10 μm. Metallic colloidal gold particles can be synthesized in sizes much smaller than micro- and nanoparticles currently being tested for drug delivery.

Type
Microscopy and Microanalysis in the Pharmaceutical Industry
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 1006 - 1007
Copyright
Copyright © Microscopy Society of America

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7. This research was funded in part by an NSF Minority Graduate Fellowship. We are greatful to Robinson, J., Cashwell, R., Massey, R., and Sims, P..Google Scholar