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Characterization of Mycobacterium bovis Phagosome

Published online by Cambridge University Press:  03 October 2008

L. Jordao ,
M. Simoes ,
C. Bleck ,
G. Griffiths  and
E. Anes
L. Jordao
Affiliation:
CPM-URIA, Faculty of Pharmacy, University of Lisbon, Avenida das Forcas Armadas, 1600-085-Lisbon, Portugal
M. Simoes
Affiliation:
CPM-URIA, Faculty of Pharmacy, University of Lisbon, Avenida das Forcas Armadas, 1600-085-Lisbon, Portugal
C. Bleck
Affiliation:
EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany
G. Griffiths
Affiliation:
EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany
E. Anes*
Affiliation:
CPM-URIA, Faculty of Pharmacy, University of Lisbon, Avenida das Forcas Armadas, 1600-085-Lisbon, Portugal
*
Corresponding author. E-mail: eanes@ff.ul.pt

Abstract

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Mycobacterium tuberculosis complex are among the most successful pathogens. Their success resides in the ability to interfere with intracellular traffic avoiding natural pathways of the phagosome maturation. Recently, mycobacteria escape from the phagosome to the cytosol was investigated as an alternative survival strategy. In this context we decided to determine the exact intracellular location of Mycobacterium bovis in different host macrophages and characterize the pathogen intracellular niche for survival. The main goal here was to characterize live vs dead M. bovis spp phagosome in different host macrophages. Macrophages infection, fluorescence and EM procedures were carried out as described previously.

Type
Abstract
Information
Microscopy and Microanalysis , Volume 14 , Supplement S3 , September 2008 , pp. 124 - 125
Copyright
Copyright © Microscopy Society of America 2008