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Cataract Formation in a Strain of Rats Selected for High Oxidative Stress

Published online by Cambridge University Press:  02 July 2020

M. J. Costello ,
S. Marsili ,
C. W. Lane ,
R. I. Salganik ,
C. D. Albright  and
R. L. Peiffer
M. J. Costello
Affiliation:
Department of Cell Biology & Anatomy, University of North Carolina, Chapel Hill, NC, 27599
S. Marsili
Affiliation:
Department of Cell Biology & Anatomy, University of North Carolina, Chapel Hill, NC, 27599
C. W. Lane
Affiliation:
Department of Cell Biology & Anatomy, University of North Carolina, Chapel Hill, NC, 27599
R. I. Salganik
Affiliation:
Department of Nutrition, University of North Carolina, Chapel Hill, NC, 27599
C. D. Albright
Affiliation:
Department of Nutrition, University of North Carolina, Chapel Hill, NC, 27599
R. L. Peiffer
Affiliation:
Department of Ophthalmology, University of North Carolina, Chapel Hill, NC, 27599
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Extract

The goals were to define the clinical and morphological characteristics of cataract formation in the OXYS strain of rats which are genetically susceptible to oxidative stress. The predominately inherited feature is the high cellular level of glucose uptake. The OXYS strain displays pathological changes in many tissues including blood vessels, liver and lung, which are consistent with increased oxidative damage. Early cataract formation is a prominent feature of this strain.

Rats were examined periodically from birth through the development of mature cataracts with slit lamp biomicroscopy. The morphology of selected stages of cataract development was studied using light and transmission electron microscopy (TEM) as well as immunohistochemical localization of lipid oxidation and DNA oxidation products. Lenses from normal rats of the same age were used as controls. OXYS rats developed cataracts as young as two weeks of age with progression to maturity by one year. Clinically, cataracts appeared initially as either nuclear or subcapsular cortical changes and developed into pronounced nuclear cataracts within months.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 590 - 591
Copyright
Copyright © Microscopy Society of America

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References

References:

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4. Supported in part by NIH Grants EY08148 and EY05722.Google Scholar