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Cell Modelling of Hematopoiesis

Published online by Cambridge University Press:  15 May 2008

N. Bessonov ,
L. Pujo-Menjouet  and
V. Volpert
N. Bessonov
Affiliation:
Institute of Mechanical Engineering Problems, 199178 Saint Petersburg, Russia
L. Pujo-Menjouet*
Affiliation:
Université de Lyon, Université Lyon 1, CNRS UMR 5208 Institut Camille Jordan F - 69200 Villeurbanne Cedex, France
V. Volpert
Affiliation:
Université de Lyon, Université Lyon 1, CNRS UMR 5208 Institut Camille Jordan F - 69200 Villeurbanne Cedex, France
*
pujo@math.univ-lyon.fr
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Abstract

In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow.

Keywords

McKendrick equationrenewal equationdemography cyclesperiodic solutionsage-structure
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 1 , Issue 2: Hematopoiesis and blood diseases , 2006 , pp. 81 - 103
Copyright
© EDP Sciences, 2006

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