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Subjective Cognitive Decline and its Relation to Verbal Memory and Sex in Cognitively Unimpaired Individuals from a Colombian Cohort with Autosomal-Dominant Alzheimer’s Disease

Published online by Cambridge University Press:  30 June 2021

Jairo E. Martinez ,
Enmanuelle Pardilla-Delgado ,
Edmarie Guzmán-Vélez ,
Clara Vila-Castelar ,
Rebecca Amariglio ,
Jennifer Gatchel ,
Daniel C. Aguirre-Acevedo ,
Yamile Bocanegra ,
Ana Baena  and
Eliana Henao
...Show all authors
Jairo E. Martinez
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Enmanuelle Pardilla-Delgado
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Edmarie Guzmán-Vélez
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Clara Vila-Castelar
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Rebecca Amariglio
Affiliation:
Department of Neurology, Center for Alzheimer Research and Treatment, Brigham, Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Jennifer Gatchel
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Daniel C. Aguirre-Acevedo
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Yamile Bocanegra
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Ana Baena
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Eliana Henao
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Victoria Tirado
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Claudia Muñoz
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Margarita Giraldo-Chica
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Francisco Lopera
Affiliation:
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
Yakeel T. Quiroz*
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
*
*Correspondence and reprint requests to: Yakeel T. Quiroz, 100 First Ave, Building 39, Suite 101, Charlestown, MA 02129, USA. Tel: (617) 643-5944; Fax: (617) 643-5896. E-mail: yquiroz@mgh.harvard.edu
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Abstract

Objective:

Subjective Cognitive Decline (SCD) may be an early indicator of risk for Alzheimer’s disease (AD). Findings regarding sex differences in SCD are inconsistent. Studying sex differences in SCD within cognitively unimpaired individuals with autosomal-dominant AD (ADAD), who will develop dementia, may inform sex-related SCD variations in preclinical AD. We examined sex differences in SCD within cognitively unimpaired mutation carriers from the world’s largest ADAD kindred and sex differences in the relationship between SCD and memory performance.

Methods:

We included 310 cognitively unimpaired Presenilin-1 (PSEN-1) E280A mutation carriers (51% females) and 1998 noncarrier family members (56% females) in the study. Subjects and their study partners completed SCD questionnaires and the CERAD word list delayed recall test. ANCOVAs were conducted to examine group differences in SCD, sex, and memory performance. In carriers, partial correlations were used to examine associations between SCD and memory performance covarying for education.

Results:

Females in both groups had greater self-reported and study partner-reported SCD than males (all p < 0.001). In female mutation carriers, greater self-reported (p = 0.02) and study partner-reported SCD (p < 0.001) were associated with worse verbal memory. In male mutation carriers, greater self-reported (p = 0.03), but not study partner-reported SCD (p = 0.11) was associated with worse verbal memory.

Conclusions:

Study partner-reported SCD may be a stronger indicator of memory decline in females versus males in individuals at risk for developing dementia. Future studies with independent samples and preclinical trials should consider sex differences when recruiting based on SCD criteria.

Keywords

Sex-differencesFamilial Alzheimer’s diseasePresenilin-1Episodic memoryPreclinical dementiaMemory disorders
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 28 , Issue 6 , July 2022 , pp. 541 - 549
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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