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RAGE and Aβ Immunoglobulins: Relation to Alzheimer’s disease-related cognitive function

Published online by Cambridge University Press:  05 May 2010

MEGHAN B. MITCHELL ,
JERRY J. BUCCAFUSCO ,
ROSANN F. SCHADE ,
SCOTT J. WEBSTER ,
SHYAMALA MRUTHINTI ,
DEAN U. HARRELL ,
NIDHI K. GULATI  and
L. STEPHEN MILLER
MEGHAN B. MITCHELL*
Affiliation:
Department of Psychology, University of Georgia, Athens, Georgia
JERRY J. BUCCAFUSCO
Affiliation:
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia Department of Research, Charlie Norwood Veteran’s Affairs Medical Center, Augusta, Georgia
ROSANN F. SCHADE
Affiliation:
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia Department of Research, Charlie Norwood Veteran’s Affairs Medical Center, Augusta, Georgia
SCOTT J. WEBSTER
Affiliation:
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia
SHYAMALA MRUTHINTI
Affiliation:
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia Department of Research, Charlie Norwood Veteran’s Affairs Medical Center, Augusta, Georgia
DEAN U. HARRELL
Affiliation:
Department of Internal Medicine, Medical College of Georgia, Augusta, Georgia
NIDHI K. GULATI
Affiliation:
Department of Family Medicine, Medical College of Georgia, Augusta, Georgia
L. STEPHEN MILLER
Affiliation:
Department of Psychology, University of Georgia, Athens, Georgia
*
*Correspondence and reprint requests to: Meghan Mitchell, Building 8, Room 1096, 200 Springs Road, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 01730. E-mail: Meghan.Mitchell2@va.gov
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Abstract

The immunoglobulins (IgGs) for beta amyloid (Aβ) and receptors for the advanced glycation end products (RAGE) have previously been shown to be related to memory and language measures in a mixed neurological sample of older adults. In this study, we examined group differences in Aβ and RAGE IgGs, as well as the relationship between both IgGs and cognitive performance in nondiabetic older adults with normal cognition, mild cognitive impairment (MCI), and probable Alzheimer’s disease (AD). We found RAGE and Aβ levels to be elevated in some AD participants, leading to significant AD–control group differences. While there was an overall correlation between both IgG levels and global cognition across all three groups, this relationship was largely attributable to group differences in cognition, highlighted by considerable variability within groups in the relationship between IgG levels and cognition. While findings do not support a consistent relationship between cognition and either IgG, further research with larger samples is needed to better characterize cognitive differences between AD participants with high versus low Aβ and RAGE titers. (JINS, 2010, 16, 672–678.)

Keywords

BiomarkersDementiaEarly detectionMemory functionBlood testImmune system function
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 4 , July 2010 , pp. 672 - 678
Copyright
Copyright © The International Neuropsychological Society 2010

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