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CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease

Published online by Cambridge University Press:  26 February 2009

Elizabeth H. Aylward ,
D. Xeno Rasmusson ,
Jason Brandt ,
Lisa Raimundo ,
Marshal Folstein  and
Godfrey D. Pearlson
Elizabeth H. Aylward
Affiliation:
Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287
D. Xeno Rasmusson
Affiliation:
Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287
Jason Brandt
Affiliation:
Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287
Lisa Raimundo
Affiliation:
Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287
Marshal Folstein
Affiliation:
Department of Psychiatry, Tufts University School of MedicineBoston, MA 02111
Godfrey D. Pearlson
Affiliation:
Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287
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Abstract

Previous studies reveal significant relationships between some quantitative computed tomography (CT) measures and level of cognitive functioning in patients with Alzheimer's disease (AD). This study was designed to determine whether measurements from CT scans of AD patients could predict future rates of decline in cognitive function. Subjects were 8 men and 19 women diagnosed with probable AD. CT measures included bifrontal ratio, bicaudate ratio, and areas of lateral ventricles, third ventricle, and suprasellar cistern (SSC). Measures of cognitive and adaptive functioning were obtained at the time of the scan and on follow-up. Of the CT measures, the SSCR (SSC corrected for intracranial area) was the most highly correlated with Mini-Mental State Exam (MMSE) score and other cognitive measures at the time of the scan. Follow-up data were obtained for those 20 individuals who were mildly to moderately demented at the time of the scan (MMSE ≥ 10). Rate of change was calculated for each neuropsychological measure. The SSCR correlated significantly with rate of change for MMSE and other measures of cognitive and adaptive functioning. This study demonstrates that CT measurement of the SSC can predict the subsequent rate of neurocognitive decline in AD patients. (JINS, 1996, 2, 89–95.)

Keywords

CTAlzheimer'sdiseaseNeuroimagingCognitive decline
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 2 , Issue 2 , March 1996 , pp. 89 - 95
Copyright
Copyright © The International Neuropsychological Society 1996

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