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Neuropsychological performance following staged bilateral pallidal or subthalamic nucleus deep brain stimulation for Parkinson's disease

Published online by Cambridge University Press:  13 December 2006

JOHANNES C. ROTHLIND ,
RANDALL W. COCKSHOTT ,
PHILIP A. STARR  and
WILLIAM J. MARKS
JOHANNES C. ROTHLIND
Affiliation:
Mental Health Service, Veterans Affairs Medical Center, San Francisco, California Department of Psychiatry, University of California, San Francisco, California Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Veterans Affairs Medical Center, San Francisco, California
RANDALL W. COCKSHOTT
Affiliation:
Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Veterans Affairs Medical Center, San Francisco, California
PHILIP A. STARR
Affiliation:
Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Veterans Affairs Medical Center, San Francisco, California Department of Neurological Surgery, University of California, San Francisco, California
WILLIAM J. MARKS
Affiliation:
Parkinson's Disease Research, Education, and Clinical Center (PADRECC), Veterans Affairs Medical Center, San Francisco, California Department of Neurology, University of California, San Francisco, California
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Abstract

Deep brain stimulation (DBS) has the potential to significantly reduce motor symptoms in advanced Parkinson's disease (PD). Controversy remains about non-motor effects of DBS and the relative advantages of treatment at two brain targets, the globus pallidus internus (GPi) and the subthalamic nucleus (STN). We investigated effects of DBS on neuropsychological functioning in 42 patients with advanced PD randomly assigned to receive staged bilateral DBS surgery of either the GPi or STN. Patients underwent neuropsychological assessment prior to and 6 months after unilateral surgery. Twenty-nine subsequently underwent surgery to the contralateral side and completed a second follow-up neuropsychological evaluation 15 months later. Unilateral treatment resulted in small but statistically significant reductions in performance on several measures, including verbal fluency and working memory. A similar pattern was observed after bilateral treatment. Reductions in verbal associative fluency were significant only after left-sided treatment. There were few significant differences related to treatment at the two surgical targets. Supplementary analyses suggested that decrements in select neuropsychological domains following DBS are unrelated to age or post-surgical reduction in dopaminergic medication dose. Findings are discussed with reference to possible causes of neuropsychological decline and the need for further controlled studies of specific neuropsychological effects of DBS. (JINS, 2007, 13, 68–79.)

Keywords

Paralysis agitansNeurosurgeryGlobus pallidusSubthalamusTreatment outcomeCognition
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 1 , January 2007 , pp. 68 - 79
Copyright
© 2007 The International Neuropsychological Society

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