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Neurobehavioral functioning in asymptomatic HIV-1 infected women

Published online by Cambridge University Press:  02 April 2001

Robert A. Stern
Affiliation:
Brown University School of Medicine, Providence, RI, USA
James E. Arruda
Affiliation:
Brown University School of Medicine, Providence, RI, USA
Jessica A. Somerville
Affiliation:
Brown University School of Medicine, Providence, RI, USA
Ronald A. Cohen
Affiliation:
Brown University School of Medicine, Providence, RI, USA
Robert J. Boland
Affiliation:
Brown University School of Medicine, Providence, RI, USA
Michael D. Stein
Affiliation:
Brown University School of Medicine, Providence, RI, USA
and Eileen M. Martin
Affiliation:
University of Illinois College of Medicine, Chicago, IL, USA

Abstract

Numerous reports have assessed the neuropsychological functioning of medically asymptomatic HIV-1 infected men. However, to date there have been no published studies of the neuropsychological functioning of asymptomatic HIV-1 infected women, even though women represent the fastest-growing demographic group of HIV-1 infected individuals. In this investigation, 31 women (17 asymptomatic HIV-1 seropositive, 14 seronegative) were administered a battery of neurocognitive and neuropsychiatric instruments. Participants in both groups were matched for age, education, months since injection drug use, and substance use. Group comparisons revealed no significant differences in any of the neurocognitive or neuropsychiatric measures. The results of this preliminary study suggest that clinically significant differences in neurobehavioral function are unlikely in medically asymptomatic HIV-1 infected women compared to seronegative controls. However, additional studies are needed with larger sample sizes and with careful attention to possible confounding or masking variables. (JINS, 1998, 4, 172–178.)

Type
Research Article
Copyright
© 1998 The International Neuropsychological Society

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Footnotes

Reprint requests to: Robert A. Stern, Neurobehavioral Research, Department of Psychiatry, Rhode Island Hospital, 110 Lockwood Street, Suite 430, Providence, RI 02903, USA. E-mail: rstern@lifespan.org.