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Preliminary dosimetric evaluation of 90Y-BPAMD as a potential agent for bone marrow ablative therapy

Published online by Cambridge University Press:  23 October 2018

Ali Rabiei ,
Hassan Yousefnia ,
Samaneh Zolghadri  and
Mojtaba Shamsaei
Ali Rabiei
Affiliation:
Energy Engineering and Physics Department, Amir Kabir University of Technology, Tehran, Iran
Hassan Yousefnia
Affiliation:
Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Samaneh Zolghadri*
Affiliation:
Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Mojtaba Shamsaei
Affiliation:
Energy Engineering and Physics Department, Amir Kabir University of Technology, Tehran, Iran
*
Author for correspondence: Samaneh Zolghadri, E-mail: szolghadri@aeoi.org.ir
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Abstract

Aim

Bone-seeking radiopharmaceuticals are potential therapeutic tools for bone marrow ablation in patients with multiple myeloma. In this procedure, estimation of radiation absorbed dose received by the target and non-target organs is one of the most important parameters that should be undertaken. This research revolves around the absorbed dose to human organs after 90Y-BPAMD injection.

Materials and methods

90Y-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (90Y-BPAMD) complex was successfully prepared under optimised conditions. The human absorbed dose of the complex was estimated based on the biodistribution data on rats using the radiation-absorbed dose-assessment resource method. The target to non-target absorbed dose ratios for the complex was compared with the ratios for 166Ho-DOTMP, as the main radiopharmaceutical for bone marrow ablation.

Results

As expected, the highest amounts of absorbed dose were observed in the bone surface and the bone marrow with 2·52 and 2·29 mGy/MBq, respectively. The red marrow to the most organ absorbed dose ratios for 90Y-BPAMD are much higher than the ratios for 166Ho-DOTMP.

Findings

90Y-BPAMD has interesting characteristics compared with 166Ho-DOTMP and can be considered as a high potential agent for bone marrow ablative therapy of the patient with multiple myeloma.

Keywords

absorbed dosebone marrow ablationBPAMD166Ho-DOTMPmultiple myelomaYttrium-90
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 18 , Issue 1 , March 2019 , pp. 70 - 74
Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Rabiei A, Yousefnia H, Zolghadri S, Shamsaei M. (2019) Preliminary dosimetric evaluation of 90Y-BPAMD as a potential agent for bone marrow ablative therapy. Journal of Radiotherapy in Practice18: 70–74. doi: 10.1017/S146039691800047X

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