Hostname: page-component-77c89778f8-5wvtr Total loading time: 0 Render date: 2024-07-17T03:48:36.392Z Has data issue: false hasContentIssue false
  • English
  • Français

Five-year survival after palliative radiotherapy of T4/N3 lung cancer: case series and review of the literature

Published online by Cambridge University Press:  22 August 2014

Federico Ampil ,
Srinivas Devarakonda ,
Carlos Previgliano  and
Glenn Mills
Federico Ampil*
Affiliation:
Department of Radiology, Louisiana State University Health, Shreveport, LA, USA
Srinivas Devarakonda
Affiliation:
Department of Medicine, Louisiana State University Health, Shreveport, LA, USA
Carlos Previgliano
Affiliation:
Department of Radiology, Louisiana State University Health, Shreveport, LA, USA
Glenn Mills
Affiliation:
Department of Medicine, Louisiana State University Health, Shreveport, LA, USA
*
Correspondence to: Federico L. Ampil, Department of Radiology, Louisiana State University Health, 1501 Kings Highway, Shreveport, LA 71130, USA. E-mail: fampil@lsuhsc.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

There is sparse literature regarding extended survival of patients treated for T4 and/or N3 lung cancers. We present the results of a case series from our radiotherapeutic experience over the last 12 years to provide additional information. Out of 189 individuals diagnosed with lung cancer between 1997 and 2008, seven treated patients who survived five years or longer were identified. The median age was 56 years. More than half of the subjects were symptomatic at the time of hospitalization, possessed voluminous, non-small-cell histologic type malignant neoplasms, and received chemotherapy also. All individuals responded to treatment, and their survival ranged from 60 to 169 months. Our observed long-term survivors seem to justify the continued practice of modern standards of care in patients with lung cancer.

Keywords

lung cancerradiotherapychemotherapysupraclavicular/mediastinal nodal metastasis
Type
Short Communication
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 1 , March 2015 , pp. 102 - 104
Copyright
© Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Jett, J R, Schild, S E, Keith, R L, Kesler, K A. Treatment of non-small cell lung cancer, stage IIIB. Chest 2007; 132: 266S–276S.CrossRefGoogle ScholarPubMed
2.Therasse, P, Arbuck, S G, Eisenhauer, E Aet al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92: 205–216.CrossRefGoogle ScholarPubMed
3.Bulbul, Y, Oztua, F, Topbas, M, Ozlu, T. Survival analysis of patients with thoracic complications secondary to bronchial carcinoma at the time of diagnosis. Respiration 2005; 72: 388–394.CrossRefGoogle ScholarPubMed
4.Michaud, A L, Chen, A M, Daly, M E. Volumetric changes in gross tumor volume during thoracic radiation therapy for small cell lung cancer: implications for adaptive replanning. Internat J Radiat Oncol Biol Phys 2013; 87 (suppl): S535.CrossRefGoogle Scholar
5.MacManus, M P, Wada, M, Matthews, J P, Ball, D L. Characteristics of 49 patients who survived for 5 years following radical radiation therapy for non-small cell lung cancer: the potential for cure. Internat J Radiat Oncol Biol Phys 2000; 46: 63–69.CrossRefGoogle Scholar
6.Quddus, AMMZ, Kerr, G R, Price, A, Gregor, A. Long-term survival in patients with non-small cell lung cancer treated with palliative radiotherapy. Clin Oncol 2001; 13: 95–98.Google ScholarPubMed
7.Wang, T, Nelson, R A, Bogardus, A, Grannis, F W Jr. Five-year lung cancer survival. Cancer 2010; 116: 1518–1525.CrossRefGoogle ScholarPubMed
8.Vos, C G, Dahele, M, Dickhoff, C, Senan, S, Thunnissen, E, Hartemink, K J. Tumor size does not predict pathological complete response rates after preoperative chemoradiotherapy for non-small cell lung cancer. Acta Oncol 2013; 52: 676–678.CrossRefGoogle Scholar