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Natural progression and clinical significance of incidentally detected pulmonary nodules in radiotherapy planning CT scans of breast cancer patients: a retrospective cohort

Published online by Cambridge University Press:  09 September 2016

Sasidharan Balu Krishna
Affiliation:
Christian Medical College Vellore, Vellore, Tamil Nadu, India
Sunitha Susan Varghese
Affiliation:
Christian Medical College Vellore, Vellore, Tamil Nadu, India
Paul Gopu Gopurathingal
Affiliation:
Christian Medical College Vellore, Vellore, Tamil Nadu, India
Venkata Krishna Reddy Pilaka
Affiliation:
Christian Medical College Vellore, Vellore, Tamil Nadu, India
Selvamani Backianathan
Affiliation:
Christian Medical College Vellore, Vellore, Tamil Nadu, India
Corresponding
E-mail address:

Abstract

Aim

Indeterminate pulmonary nodules incidentally detected during radiological imaging completed for radiotherapy planning always creates dilemma for the oncologist. The purpose of this study is to evaluate the clinical significance of pulmonary nodules incidentally detected in patients undergoing locoregional radiotherapy for breast cancer and present a retrospective analysis of the natural progression of such nodules.

Methods

A retrospective review of computed tomography scans of breast cancer patients who underwent radiotherapy over a period of 3 years to screen out patients with indeterminate lung nodules was undertaken. This was correlated with the patient and tumour characteristics and the status of the disease at last follow-up.

Results

Of the 132 patients reviewed 28 had indeterminate lung nodules. Of the 28 patients, four had progressive lung nodules on follow-up. Subgroup analyses did not show any significant correlation.

Discussion and conclusion

One fifth of patients may present with incidentally detected lung nodules. Multiple nodules, ER negative status and locally advanced breast cancer may point to a higher risk of these nodules progressing to metastatic cancer. There is no indication to stop locoregional therapy in the presence of indeterminate nodules, but close follow-up of high-risk group is recommended.

Type
Original Articles
Copyright
© Cambridge University Press 2016 

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References

1. Ferlay, J, Shin, H-R, Bray, F, Forman, D, Mathers, C, Parkin, D M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127 (12): 28932917.CrossRefGoogle ScholarPubMed
2. Gonzalez-Angulo, A M, Morales-Vasquez, F, Hortobagyi, G N. Overview of resistance to systemic therapy in patients with breast cancer. Adv Exp Med Biol 2007; 608: 122.CrossRefGoogle ScholarPubMed
3. Meimarakis, G, Rüttinger, D, Stemmler, J et al. Prolonged overall survival after pulmonary metastasectomy in patients with breast cancer. Ann Thorac Surg 2013; 95 (4): 11701180.CrossRefGoogle ScholarPubMed
4. Naidich, D P, Bankier, A A, MacMahon, H et al. Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner society. Radiology 2013; 266 (1): 304317.CrossRefGoogle ScholarPubMed
5. Gould, M K, Donington, J, Lynch, W R et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Chest 2013; 143 (5 suppl): e93Se120S.CrossRefGoogle ScholarPubMed
6. Lee, B, Lim, A, Lalvani, A et al. The clinical significance of radiologically detected silent pulmonary nodules in early breast cancer. Ann Oncol 2008; 19 (12): 20012006.CrossRefGoogle ScholarPubMed
7.TB Statistics for India – National and state statistics [Internet]. TB Facts.org. http://www.tbfacts.org/tb-statistics-india/. Accessed on January 10th 2016.Google Scholar
8. Quint, L E, Park, C H, Iannettoni, M D. Solitary pulmonary nodules in patients with extrapulmonary neoplasms. Radiology 2000; 217 (1): 257261.CrossRefGoogle ScholarPubMed
9. Daglar, G, Yuksek, Y N, Gozalan, U, Tutuncu, T, Kama, N A. The significance of pulmonary nodule in breast cancer patients. Bratisl Lekárske Listy 2010; 111 (5): 280283.Google ScholarPubMed

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Natural progression and clinical significance of incidentally detected pulmonary nodules in radiotherapy planning CT scans of breast cancer patients: a retrospective cohort
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Natural progression and clinical significance of incidentally detected pulmonary nodules in radiotherapy planning CT scans of breast cancer patients: a retrospective cohort
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