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In vivo dosimetry using radiochromic films (EBT-2) during intraoperative radiotherapy

Published online by Cambridge University Press:  06 June 2016

Zahra Rahimzade Yekta
Affiliation:
Sciences and Research Branch of Tehran, Islamic Azad University, Tehran, Iran
Seied Rabi Mehdi Mahdavi
Affiliation:
Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
Hamid Reza Baghani
Affiliation:
Department of Radiation Medicine, Shahid Beheshti University, Tehran, Iran
Mostafa Robatjazi
Affiliation:
Department of Medical Physics, Tehran University of medical Science, Tehran, Iran
Ahmad Mostaar
Affiliation:
Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hamidreza Mirzaie
Affiliation:
Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Dariush Sardari
Affiliation:
Sciences and Research Branch of Tehran, Islamic Azad University, Tehran, Iran
Mohammad Esmaeil Akbari
Affiliation:
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nahid Nafisi
Affiliation:
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Corresponding
E-mail address:

Abstract

Background

Intraoperative radiotherapy is a method of choice to deliver a critical radiation dose to the tumour bed immediately after surgical excision.

Aim

The purpose of this work is to check the dose delivered to the patients during intraoperative electron beam radiation therapy (IOERT) in the conservative treatment of breast cancer, by means of reference dose measurement using radiochromic (EBT-2) films.

Material and methods

Ninety patients with early-stage breast cancer underwent exclusive IOERT to the tumour bed using a LIAC linear accelerator. Absolute dose measurements were done with film pieces. After irradiation, the pixel values of the films were obtained via MATLAB and ImageJ softwares. Calibration curve was also used for calculating net optical density. Expected dose was compared to the patient delivered dose.

Results

The mean deviation of the delivered dose from the expected one was 2·56% that is well in the accepted criteria. Only in one case, there was a larger deviation due to barometer miscalibration.

Findings

EBT-2 film response is independent from dose-per-pulse and as it was shown in this study it can be robustly used during breast IOERT for dosimetric and also positioning verifications.

Type
Original Articles
Copyright
© Cambridge University Press 2016 

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References

1. Hirokazu, M, Yutaka, T, Atsushi, T. Homogeneity of Gafchromic Film among different lot numbers. J Clin Med Phys 2012; 13 (4). ISSN 15269914. http://www.jacmp.org/index.php/jacmp/article/view/3763. Accessed on 30th April 2016.Google Scholar
2. Ishikura, S. Quality assurance of radiotherapy in cancer treatment: toward improvement of patient safety and quality of care. Jpn J Clin Oncol 2008; 38 (II): 723729.CrossRefGoogle ScholarPubMed
3. Trifiletti, D M, Jones, R, Showalter, S L et al. Techniques for intraoperative radiation therapy for early-stage breast carcinoma. Future Oncol 2015; 11 (7): 10471058.CrossRefGoogle ScholarPubMed
4. Vasile, G, Vasile, M, Duliu, O G. In-vivo dosimetry measurement for breast radiation treatments. Rom Rep Phys 2012; 64 (3): 728736.Google Scholar
5. Robatjazi, M, Mahdavi, R, Takavar, A, Baghani, H. Application of Gafchromic EBT-2 film for intraoperative radiation therapy quality assurance. Physica Media 2015; 31 (3): 314315.CrossRefGoogle Scholar
6. Perry, N, Broeders, M, Wolf, C. European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis. UK, The Netherlands, Switzerland: Health and Consumer Protection, 2006.Google ScholarPubMed
7. Olaf, N, Heinz, D, Michael, K et al. A dosimetric comparison of IORT techniques in limited-stage breast cancer. Strahlenther Onkol 2006; 6: 342348.Google Scholar
8. Nairz, O, Deutschmann, H, Kopp, M. A dosimetric comparison of IORT techniques in limited-stage breast cancer. Strahlenther Onkol 2006; 182: 342348.CrossRefGoogle ScholarPubMed
10. Carrasco, M A, Perucha, M, Luis, F J, Baeza, M, Herrador, M. A comparison between radiochrmic EBT2 film model and its predecessor EBT film model. Physica Medica 2012; 10: 1016.Google Scholar
11. Slobodan, D. Radiochrmic film dosimetry: past, present, and future. Physica Medica 2011; 27: 122134.Google Scholar
12. Van Wieringen, N, van Herten, Y R J, van de Kamer, J B, Erogluer, A, Bel, A, Wiersma, J. Development of a QA procedure for IMRT plans using EBT radiochromic film. Radiother Oncol 2007; 84: S206.Google Scholar
13. Todorovic, M, Fischer, M, Cremers, F, Thom, E, Schmidt, R. Evaluation of Gafchromic EBT prototype B for external beam dose verification. Med Phys 2006; 33: 13211328.CrossRefGoogle ScholarPubMed
14. Rink, A, Vitkin, I A, Jaffray, D A. Energy dependence (75 kVp to 18 MV) of Radiochromic films assessed using a real-time optical dosimeter. Med Phys 2007; 34: 458463.CrossRefGoogle ScholarPubMed
15. Lynch, B D, Kozelka, J, Ranade, M K, Li, J G, Simon, W E, Dempsey, J F. Important considerations for radiochromic film dosimetry with flatbed CCD scanners and EBT GAFCHROMIC film. Med Phys 2006; 33: 45514556.CrossRefGoogle ScholarPubMed
16. Sim, G S, Wong, J H, Ng, K H. The use of radiochromic EBT2 film for the quality assurance and dosimetric verification of 3D conformal radiotherapy using Microtek scan maker 9800XL flatbed scanner. J Appl Clin Med Phys 2013; 14: 8595.CrossRefGoogle Scholar
17. Girard, F, Bouchard, H, Lacroix, F. Reference dosimetry using radio chromic film. Am Assoc Phys Med 2012; 13 (6). ISSN 15269914. http://www.jacmp.org/index.php/jacmp/article/view/3994/2740. Accessed on 30th April 2016.Google Scholar
18. Reinhardt, S, Hillbrand, M, Wilkens, J J, Assmann, W. Comparison of gafchromic EBT2 and EBT3 films for clinical photon and proton beams. Med Phy 2012; 39: 00942405.CrossRefGoogle ScholarPubMed
19. Hartmann, B, Martišíková, M, Jäkel, O. Homogeneity of gafchromic EBT2 film. Med Phys 2010; 1753–6: 23942405.Google Scholar
20. Rink, A, Vitkin, I A, Jaffray, D A. Characterization and real-time optical measurements of the ionizing radiation dose response for a new radiochromic medium. Med Phys 2005; 32: 25102516.CrossRefGoogle ScholarPubMed
21. Martisikova, M, Ackermann, B, Ja¨kel, O. Analysis of uncertainties in Gafchromic EBT film dosimetry of photons beams. Phys Med Biol 2008; 53: 7013e27.CrossRefGoogle ScholarPubMed
22. Lorenz, F, Nalichowski, A, Rosca, F, Kung, J, Wenz, F, Zygmanski, P. Spatial dependence of MLC transmission in IMRT delivery. Phys Med Biol 2007; 52: 5985e99.CrossRefGoogle ScholarPubMed
23. Fontana Rosa, D, Orlandini, L, Andriani, I, Bernardi, L. Commissioning varian enhanced dynamic wedge in the PINNACLE treatment planning system using gafchromic EBT film. Med Phys 2009; 36: 4504e10.Google Scholar
25. Righi, S, Karaj, E, Felici, G. Dosimetric characteristics of electron beams produced by two mobile accelerators, Novac7 and LIAC, for intraoperative radiation therapy through Monte Carlo simulation. Journal of Applied Clinical Medical Physics 2013; 14 (1). ISSN 15269914. http://jacmp.org/index.php/jacmp/article/view/3678. Accessed on 30th April 2016.Google Scholar

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