Hostname: page-component-7479d7b7d-q6k6v Total loading time: 0 Render date: 2024-07-12T02:25:53.747Z Has data issue: false hasContentIssue false
  • English
  • Français

Tissue Levels of Chlorpromazine in Experimental Animals

Published online by Cambridge University Press:  08 February 2018

Magdalena Berger Wechsler  and
Leon Roizin
Magdalena Berger Wechsler
Affiliation:
Department of Experimental Psychiatry, New York State Psychiatric Institute, New York, N.Y., and Department of Biochemistry, College of Physicians and Surgeons, Columbia University
Leon Roizin
Affiliation:
Department of Neuropathology, New York State Psychiatric Institute, New York, N.Y., and Department of Pathology, College of Physicians and Surgeons, Columbia University
Get access Rights & Permissions [Opens in a new window]

Extract

The increasing use of tranquillizers in the treatment of mental disorders has made it imperative to study both the immediate and long-term effects of these drugs in order to establish their limits of safety. One of the approaches that appeared important to us was the correlation of the histological findings (Roizin, True and Knight, 1959) with tissue levels of the drug. In addition to its significance from the pathological standpoint, such a study may also furnish information towards a better understanding of the mechanism of action of these drugs.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1501 - 1505
Copyright
Copyright © Royal College of Psychiatrists, 1960 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berger, M., J. Neurochem., 1957, 2, 30.CrossRefGoogle Scholar
Fedorov, N. A., and Schnol, C. E., Zhur. Neuropat. Psych. (Moscow), 1956, 2, 139.Google Scholar
Idem , ibid., 1957, 6, 761.Google Scholar
Roizin, L., True, C., and Knight, M., Proc. Assoc. Res. Nerv. Ment. Dis., 1959, 37, 285. Baltimore: Williams ' Wilkins Co. Google Scholar
Salzman, N. P., and Brodie, B. B., J. Pharmacol., 1956, 118, 46.Google Scholar
Wase, A. W., Christensen, J., and Polley, E., Arch. Neurol. Psych., 1956, 75, 54.Google Scholar
Wechsler, , Berger, M., and Forrest, I. S., J. Neurochem., 1959. In press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.