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Controlled Clinical Trial of Isocarboxazid (“Marplan”) in Hospital Psychiatry

Published online by Cambridge University Press:  08 February 2018

Vasant G. Joshi
Vasant G. Joshi*
Affiliation:
St. Francis Hospital, Haywards Heath, Sussex
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Extract

A number of synthetic drugs have recently been introduced as specific antidepressants in psychiatry. Isocarboxazid (Marplan) is an analogue of iproniazid (Marsilid). Both belong to the monoamine oxidase inhibitor group of antidepressants. Isocarboxazid is said to be less toxic but of equal potency for a lesser dose than iproniazid. A controlled clinical trial of isocarboxazid was therefore undertaken to assess this drug in the treatment of depression. The results of this trial are reported in this paper together with the results of an uncontrolled trial in a further group of patients (group M) who received isocarboxazid only.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 448 , May 1961 , pp. 567 - 571
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

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