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Mechanical response of human red blood cells in health and disease: Some structure-property-function relationships

Published online by Cambridge University Press:  01 August 2006

S. Suresh
S. Suresh*
Affiliation:
Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307
*
a) Address all correspondence to this author. e-mail: ssuresh@mit.edu
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Abstract

Aspects of mechanical deformability and biorheology of the human red blood cell are known to play a pivotal role in influencing organ function as well as states of overall health and disease. In this article, consequences of alterations to the membrane and cytoskeletal molecular structure of the human red blood cell are considered in the context of an infectious disease, Plasmodium falciparum malaria, and several hereditary hemolytic disorders: spherocytosis, elliptocytosis, and sickle cell anemia. In each of these cases, the effects of altered cell shape or molecular structure on cell elasticity, motility, and biorheology are examined. These examples are used to gain broad perspectives on the connections among cell and subcellular structure, properties, and disease at the intersections of engineering, biology, and medicine.

Keywords

AdhesionBiomedical
Type
Reviews
Information
Journal of Materials Research , Volume 21 , Issue 8 , August 2006 , pp. 1871 - 1877
Copyright
Copyright © Materials Research Society 2006

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