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Drug–matrix interactions in nanostructured materials containing fluoxetine using sol-gel titanium oxide as a matrix

Published online by Cambridge University Press:  13 September 2011

Mayra González ,
Jacques Rieumont ,
Francois Figueras  and
Patricia Quintana
Mayra González*
Affiliation:
Engineering and Chemical Research Center, C.P. 10600, C. Havana City, Cuba; and Polymer Lab, Institute of Materials Science and Technology, University of Havana, C.P. 10400, C. Havana City, Cuba
Jacques Rieumont
Affiliation:
Department of Physical Chemistry, Faculty of Chemistry, University of Havana, C.P. 10600, Havana City, Cuba
Francois Figueras
Affiliation:
Institut de Recherche sur la Catalyse et l’Environnement de Lyon, UMR 5256, Villeurbanne, France
Patricia Quintana
Affiliation:
Department of Applied Physics, CINVESTAV-IPN, Mérida, A.P. 73, Cordemex, C.P. 97310, Mérida, Yucatán, México
*
a)Address all correspondence to this author. e-mail: mayra.hurtado@infomed.sld.cu
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Abstract

Titanium oxide matrix was prepared by sol-gel adding fluoxetine [Prozac (C17H18NF3O)] during the reaction of gelation. This nanostructured material was studied by Fourier transform infrared (FTIR) spectroscopy, N2 adsorption, and x-ray diffraction to detect the interaction between the drug and the matrix. The complex nature of FTIR signals for the matrix and the drug did not allow observation of the interactions; however, using the density functional theory formalism, two stable complexes are suggested to be formed on the drug–matrix system. Both complexes are formed through H bond interactions involving the amine group in fluoxetine and the hydroxylated sites in titanium xerogel. They were found to be energetically stable and independent of the titanium model core cluster used in the calculations.

Keywords

StructuralSol-gelNanostructure
Type
Articles
Information
Journal of Materials Research , Volume 26 , Issue 22 , 28 November 2011 , pp. 2871 - 2876
Copyright
Copyright © Materials Research Society 2011

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