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Topical treatment of eczematous external otitis involving the ear canal: long-term results of a trial comparing pimecrolimus 1 per cent versus clobetasone butyrate 0.05 per cent

Published online by Cambridge University Press:  07 January 2022

Z Nemeth ,
E Verga Open the ORCID record for E Verga [Opens in a new window]  and
R Verdolini
Z Nemeth
Affiliation:
Department of ENT, Princess Alexandra Hospital NHS Trust, Harlow, UK
E Verga*
Affiliation:
Department of Dermatology, Princess Alexandra Hospital NHS Trust, Harlow, UK
R Verdolini
Affiliation:
Department of Dermatology, Princess Alexandra Hospital NHS Trust, Harlow, UK
*
Author for correspondence: Dr Emanuele Verga, Department of Dermatology, Princess Alexandra Hospital NHS Trust, Harlow, UK E-mail: e.verga@nhs.net
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Abstract

Background

Eczematous external otitis is a common chronic condition that can have a significant impact on the life of sufferers, causing constant discomfort and pruritus, and leading to sleep deprivation. Treatment is based on the use of topical steroids, moisturisers and occasionally antibiotics. Results, however, can be disappointing, especially over the long term.

Methods

This study compared the long-term response to pimecrolimus, administered to a group of 11 patients, against clobetasone butyrate, administered to an equivalent number of patients. Response to the treatment was assessed and statistically analysed at 3 and 12 months.

Conclusion

Whereas the degree of improvement following the use of pimecrolimus and clobetasone butyrate was similar for the two groups at month 3, a highly statistically significant difference was documented at month 12, with a much greater and sustained improvement in the pimecrolimus group.

Keywords

Eczematous DisordersExternal OtitisTopical AdministrationPimecrolimusCalcineurin InhibitorsSteroidsClobetasone ButyrateExternal EarEar Canal
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 7 , July 2022 , pp. 635 - 638
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr E Verga takes responsibility for the integrity of the content of the paper

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