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Substance P-like immunoreactivity in the rabbit inner ear

Published online by Cambridge University Press:  29 June 2007

Jukka Ylikoski ,
Liisa Eränkö  and
Heikki Päivärinta
Jukka Ylikoski*
Affiliation:
Associate Professor, Department of Otolaryngology, University of Helsinki, Finland.
Liisa Eränkö
Affiliation:
Associate Professor, Department of Anatomy, University of Helsinki, Finland.
Heikki Päivärinta
Affiliation:
Assitant Professor, Department of Anatomy, University of Helsinki, Finland.
*
Department of OtolaryngologyUniversity of Helsinki, Haartmanninkatu 4ESF-00290 Helsinki 29Finland.
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Abstract

Abstract The auditory and vestibular sense-organs of the rabbit were examined for the presence of substance P(SP) by an immunohistochemical technique using a monoclonal SP-antibody. Between 30 and 40 per cent of the cells of the vestibular ganglia and about 50 per cent of the spiral ganglion cells innervating the extreme basal part of the cochlea showed SP-like immunoreactivity. The neural elements in the vestibular sensory epithelia, notably the calyx-formed nerve terminals of type 1 sensory cells of the maculae, also showed strong SP-like immunoreactivity. The findings suggest the possibility of a modulator or transmitter role for SP in the inner ear function.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 8 , August 1984 , pp. 759 - 765
Copyright
Copyright © JLO (1984) Limited 1984

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