Hostname: page-component-77c89778f8-fv566 Total loading time: 0 Render date: 2024-07-16T21:29:31.665Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum adenosine deaminase and total superoxide dismutase activities before and after surgical removal of cancerous laryngeal tissue

Published online by Cambridge University Press:  29 June 2007

Orhan Canbolat ,
Ömer Akyol ,
Mustafa Kavutcu ,
A. Ümit Isik  and
Ilker Durak
Orhan Canbolat
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
Ömer Akyol
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
Mustafa Kavutcu
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
A. Ümit Isik
Affiliation:
Ankara Numune Hospital, Ankara, Turkey
Ilker Durak*
Affiliation:
Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey
*
Dr Ilker Durak, Ankara Üniversitesi Tip fakültesi, Biyokimya Anabilim Dali (Dekanlik Binasi), 06100-Sihhiye, Ankara, Turkiye
Get access Rights & Permissions [Opens in a new window]

Abstract

In this study, pre- and post-operative serum activities of adenosine deaminase (ADA) and total superoxide dismutase (SOD) enzymes were measured in patients with squamous cell laryngeal cancer. Activities of both enzymes were found to be higher in cancerous patients compared to the controls. No significant differences were found however between pre- and post-operative values for both enzymes in the patient group.

It has been suggested that ADA and SOD enzymes leak from the cancerous laryngeal tissues into the blood stream. The absence of differences between pre- and post-operative serum enzyme activities has two possible explanations: Firstly, removal of previously released enzymes from the blood stream takes a much longer period than one month; and secondly, cancerous laryngeal tissue is not the only source of the enzymes mentioned even after removal of cancerous tissue by surgical operation, other sources such as adjacent tissues and/or metastatic tissues etc, still release these enzymes into the blood stream.

Keywords

Adenosine deaminaseSuperoxide dismutaseLaryngeal neoplasmscarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 10 , October 1994 , pp. 849 - 851
Copyright
Copyright © JLO (1984) Limited 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Deegan, M. J., Coulthard, S. W., Qualman, S. J., (1977) A correlation analysis of in vitro parameters of cellular immunity in patients with squamous cell carcinoma of the head and neck. Cancer Research 37: 4475–4481.Google Scholar
Durak, I., Canbolat, O., Yurtarslani, Z., Akyol, Ö. (1993) A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium reduction. Clinica Chimica Acta 214: 103–104.CrossRefGoogle Scholar
Formeister, J. F., Tritsch, G. L. (1976) Adenosine deaminase levels in blood type A patients with metastatic tumor. Surgery 79: 111–117.Google ScholarPubMed
Guisti, G. (1974). Adenosine Deaminase, (Bergmeyer, H. U. Ed). Academic Press, New York, pp 1092.Google Scholar
Kawamura, N., Suziki, K., Ishikava, M., Lizuka, S., Miyaka, M., Nakato, M., Taniguchi, N. (1992) High levels of Mn-SOD in serum of patients with neuroblastoma and in human neuroblastomacell lines. Free Radical Biology and Medicine 12: 281–286.CrossRefGoogle Scholar
Kwee, J. K., Mitidieri, E.Alfonso, O. R. (1991) Lowered superoxide dismutase in highly metastatic B16 melanoma cells. Cancer (Letter) 57: 199–202.Google ScholarPubMed
Lai, H., Munjal, S. K., Wig, U., Saini, A. S. (1987) Serum enzymes in head and neck cancer: III. Journal of Laryngology and Otology 101: 1062–1065.Google Scholar
Madei, J. A., Kaszubkievicz, C., Radzonowska, G. (1988) Superoxide dismutase, catalase and glutathione peroxidase activities in mice with natural lymphocytic leukemia. Poland Archive Weter 28: 25–34.Google Scholar
Morisaki, T., Fujii, H., Miwa, S. (1985) Adenosine deaminase (ADA) in leukemia. Clinical value of plasma ADA activity and characterisation of leukemia cell ADA. American Journal of Hematology 19: 37–45.CrossRefGoogle ScholarPubMed
Nishihara, H., Akedo, K., Okada, H., Haltor, S. (1970) Multienzyme patterns of serum adenosine deaminase by agar gel electrophoresis: an evaluation of the diagnostic value in lung cancer. Clinica Chimica Acta 30: 251–258.Google ScholarPubMed
Symth, J. F., Harrap, K. R. (1975) Adenosine deaminase activity in leukemia. British Journal of Cancer 31: 544–549.CrossRefGoogle Scholar
Storch, H., Kriiger, W., Rotzch, W. (1981) Adenosine deaminase activity in plasma and blood cells of patients with haematological and autoimmune diseases. Ada Haematologica 65: 183–188.CrossRefGoogle ScholarPubMed
Sufrin, G., Tritsch, G. L., Mittelman, A., Murphy, G. P. (1978) Adenosine deaminase activity in patients with carcinoma of bladder. Journal of Urology 119: 343–346.CrossRefGoogle Scholar
Sun, Y., Oberley, L. W., Li, Y. (1988) A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34: 497–500.CrossRefGoogle ScholarPubMed
Taniguchi, N. (1990) Superoxide dismutase. Significances in aging, diabetes, ischemia and cancer. Rinsho Byori 38: 376–881.Google ScholarPubMed
Uberti, J., Johnson, R. M., Talley, R., Lightbody, J. J. (1976) Decreased lymphocyte adenosine deaminase activity in tumor patients. Cancer Research 36: 2046–2047.Google ScholarPubMed
Van Laarhoven, J. P., Spirenburg, G. T, Bakkeren, A., Schouten, T. J., De Byum, C. H., Geerts, S. J., Schretlen, F. D. (1983) Purine metabolism in childhood acute lymphocytic leukemia: Biochemical markers for diagnosis and chemotherapy. Leukemia Research 7: 407–420.CrossRefGoogle Scholar
Wei, L. K. (1991) The clinical and laboratory studies of superoxide dismutase activity in the human whole blood with early gastric cancer. Free Radical Research Communication 12: 759–760.Google ScholarPubMed