Hostname: page-component-77c89778f8-swr86 Total loading time: 0 Render date: 2024-07-17T09:07:51.707Z Has data issue: false hasContentIssue false
  • English
  • Français

Rhabdomyosarcoma of the adult head and neck: a clinicopathological and DNA ploidy study

Published online by Cambridge University Press:  29 June 2007

Adel K. El-Naggar ,
John G. Batsakis ,
Nelson G. Ordónez ,
Mario A. Luna  and
Helmuth Goepfert
Adel K. El-Naggar*
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
John G. Batsakis
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Nelson G. Ordónez
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Mario A. Luna
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
Helmuth Goepfert
Affiliation:
Deparments of Pathology, the University of Texas, M. D. Anderson Cancer Center, Houston Texas
*
Adel K. El-Naggar, M. D., Department of Pathology, The University of Texas, M. D. Anderson Cancer Center, Box 85, 1515 Holcombe Blvd., Houston, Texas 77030.
Get access Rights & Permissions [Opens in a new window]

Abstarct

We investigated the DNA ploidy patten in thirteen primary and four recurrent rhabdomyosarcomas of teh head and neck from thirteen adult patients and conrrelated the findings with other clinicopathological factors and clinical outcome. Twelve (92.7 per cent) of the primary neoplasms manifested an aneuploid DNA pattern. All recurrent lesions were DNA aneuploid with DNA indices (DIs) Corresponding to their primary neoplasms. No correlation beteween the ploidy pattern and histological subtypes, tumours location, clinical stage and patient's clinical course was found. In this study, only two patients were long-term, survivors. Both patients had stage I neoplasms that were located in non-parameninigeal sites which manifested an alvellar histological pattern. Our data indicate that adult rhabdoyosarcomas of adult and neck are preponderantly DNA aneuploid and are highly aggressive malignant neoplasms. Our results alson suggest that tumours which are low stage and in a non-parameningeal location may pursue a less aggressive course.

Keywords

RhabdomysarcomaFlow cytometryDNA
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 8 , August 1993 , pp. 716 - 720
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barr, F.G., Biegel, J.A., Sellinger, B., Womer, R.B., Emanuel, B.S. (1991) Molecular and cytogenetic analysis of chromosomal arms 2q and 13q in alveolar rhabdomyosarcoma. Genes, Chromosomes and Cancer 3: 153–161Google Scholar
Boyle, E.T., Reiman, H.M., Kramer, S.A., Kelalis, P.P., Rainwater, L.M., Lieber, M.M. (1988) Embryonal rhabdomyosarcoma of bladder and prostate: nuclear DNA patterns studied by flow cytometry. Journal of Urology 140: 1119–1121CrossRefGoogle ScholarPubMed
Donaldson, S.S. (1989) Rhabdomyosarcoma: contemporary status and future direction. Archives Surgery 124: 1015–1020Google Scholar
Gansler, T., Chatten, J., Varello, M., Bunin, G.R., Atkinson, B. (1986) Flow cytometric DNA analysis of neuroblastoma. Correlation with histology and clinical outcome. Cancer 58: 2453–24583.0.CO;2-I>CrossRefGoogle ScholarPubMed
Hays, D.M., Newton, W., Soule, E.H., Foulkes, M.A., Raney, R.B., Tefft, M., Ragab, A., Maurer, H.M. (1983) Mortality among children with rhabdomyosarcoma of the alveolar histologic subtype. Journal of Pediatric Surgery 18: 412–417.CrossRefGoogle ScholarPubMed
Johnston, D.A., White, R.A., Barlogie, B. (1978) Automated processing and interpretation of DNA distributions: comparison of several techniques. Computers and Biomedical Research 11: 393–404Google Scholar
Kowal-Vern, A., Gonzalez-Crussi, F., Turner, J., Trujillo, Y.P., Chou, P., Herman, C.Castelli, M., Walloch, J. (1990) How and image cytometric DNA analysis in rhabdomyosarcoma. Cancer Research 50: 6023–6027Google ScholarPubMed
Kumar, P.D., Marsden, H.B., Gattamaneni, H.R., Heighway, J., Kumar, S. (1990) N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. International Journal of Cancer 45: 593–596Google Scholar
Lloyd, R.V.Hajdu, S.I., Knapper, W.H. (1983) Embryonal rhabdomyosarcoma in adults. Cancer 51: 557–5653.0.CO;2-E>CrossRefGoogle ScholarPubMed
Look, A.T., Melvin, S.L., Williams, D.L., Brodeur, G.M., Dahl, G.V.Kalwinsky, D.K., Murphy, S.B., Mauer, A.M. (1982) Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia. Blood 60: 959–967Google Scholar
Look, A.T., Hayes, F.A., Nitschke, R., McWilliams, N.B., Green, A.A. (1984) Cellular DNA content as a predictor of response to chemotherapy in infants with unrespectable neuroblastoma. New England Journal of Medicine 311: 231–235CrossRefGoogle Scholar
Maurer, H.M. (1975) The Intergroup Rhabdomyosarcoma Study (NIH): objectives and clinical staging classification. Journal of Pediatric Surgery 10: 977–978CrossRefGoogle Scholar
Maurer, H.M., Beltangady, M.Gehan, E. A., Crist, W., Hammond, D., Hays, D.M., Heyn, R., Lawrence, W.Newton, W., Ortega, J., Ragab, A.H., Raney, R.B., Ruymann, F.B., Soule, E., Tefft, M., Webber, B., Wharam, M., Vietti, T.J. (1988) The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer 61:209–2203.0.CO;2-L>CrossRefGoogle ScholarPubMed
McLemore, D.D., El-Naggar, A. K., Stephens, L.C.Jardine, J. (1990) Modified methodology to improve flow cytometric DNA histograms from paraffin-embedded material. Stain Technology 65: 279–291Google Scholar
Molenaar, W.M., Dam-Meiring, A., Kamps, W.A., Cornelisse, C.J. (1988) DNA-aneuploidy in rhabdomyosarcoma as compared with other sarcomas of childhood and adolescence. Human Pathology 19: 573–579CrossRefGoogle ScholarPubMed
Nakhleh, R.E., Swanson, P.E., Dehner, L.P. (1991) Juvenile (embryonal and alveolar) rhabdomyosarcoma of the head andm neck in adults A clinical, pathologic and immunohistochemical study of 12 cases. Cancer 67: 1019–10243.0.CO;2-7>CrossRefGoogle Scholar
Newman, A.N., Rice, D.H. (1984) Rhabdomyosarcoma of the head and neck. Laryngoscope 94: 234–239.CrossRefGoogle ScholarPubMed
Ordónez, N.G., Manning, J.T., Brooks, T.E. (1988) Effect of trypsinization on the immunostaining of formalin-fixed, paraffinembedded tissues. American Journal of Surgical Pathology 12: 121–129CrossRefGoogle ScholarPubMed
Pizzo, P.A., Triche, T.J. (1987) Clinical staging in rhabdomyosarcoma: current limitations and future prospects. Journal of Clinical Oncology 5: 8–9CrossRefGoogle ScholarPubMed
Potluri, V.R., Gilbert, F. (1985) A cytogenetic study of embryonal rhabdomyosarcoma. Cancer Genetics and Cytogenetics 14: 169–173CrossRefGoogle ScholarPubMed
Prestidge, B.R., Donaldson, S.S. (1989) Treatment results among adults with childhood tumors: a 20-year experience. International Journal of Radiation Biology 17: 507–514Google Scholar
Raney, R.B., Crist, W.M., Maurer, H.M., Foulkes, M.A. (1983) Prognosis of children with soft tissue sarcoma who relapse after achieving a complete response. A report from the Intergroup Rhabdomyosarcoma Study-I. Cancer 52: 44–503.0.CO;2-V>CrossRefGoogle ScholarPubMed
Rodriguez, E., Reuter, V.E., Mies, C.Bosl, G. J., Chaganti, R.S. K. (1991) Abnormalities of a common genetic link between rhabdomyosarcoma and hypatoblastoma. Genes, Chromosomes and Cancer 3: 122–127CrossRefGoogle Scholar
Schmidt, D., Wiedemann, B., Keil, W., Sprenger, E., Harms, D. (1986) Flow cytometric analysis of nephroblastomas and related neoplasms. Cancer 58: 2494–25003.0.CO;2-J>CrossRefGoogle ScholarPubMed
Scrable, H.J., Witte, D.P., Lampkin, B.C.Covenee, W.K. (1987) Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature 329: 645–647Google Scholar
Seidal, T., Mark, J., Hagmar, B., Angervall, L. (1982) Alveolar rhabdomyosarcoma: a cytogenetic and correlated cytological and histological study. APMIS; Ada Pathologica Microbiologica et Immunologica Scandinavica 90: 345–354Google ScholarPubMed
Shapiro, D.N., Parham, D.M.Douglass, E.C.Ashmun, R., Webber, B.L., Newton, W.A., Hancock, M.L., Maurer, H.M., Look, A.T. (1991) Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unrespectable rhabdomyosarcoma. Journal of Clinical Oncology 9: 159–166Google Scholar
Sutow, W.W., Lindberg, R.D., Gehan, E.A., Ragab, A.H., Raney, R.B. (1982) Three-year relapse-free survival rates in childhood rhabdomyosarcoma of the head and neck. Report from the Intergroup Rhabdomyosarcoma Study. Cancer 49: 2217–2221Google Scholar
Trent, J., Casper, J., Meltzer, P., Thompson, E.Fogh, J. (1985) Nonrandom chromosome alterations in rhabdomyosarcoma. Cancer Genetics and Cylogenetics 16: 189–197.CrossRefGoogle ScholarPubMed
Wang-Wuu, S., Soukup, S., Ballard, E., Gotwals, B., Lampkin, B. (1988) Chromosomal analysis of sixteen human rhabdomyosarcomas. Cancer Research 48: 983–987Google Scholar