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Prediagnostic malakoplakia presenting as a chronic inflammatory mass in the soft tissues of the neck

Published online by Cambridge University Press:  29 June 2007

A. G. Douglas-Jones*
Affiliation:
Departments of ENT and Pathology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN.
C. Rodd
Affiliation:
Departments of ENT and Pathology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN.
E. M. V. James
Affiliation:
Departments of ENT and Pathology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN.
R. G. S. Mills
Affiliation:
Departments of ENT and Pathology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN.
*
Dr A. G. Douglas-Jones, Pathology Department, University Hospital of Wales, Heath Park, Cardiff, South Glamorgan CF4 4XN.

Abstract

Malakoplakia presenting in the head and neck is very rare. We present a case of an inflammatory mass in the neck, clinically mimicking actinomycosis in a 67-year-old man. Repeated culture of E. coli and histological and electron microscopic examination of biopsy material showed an infiltration of granular macrophages and intracellular gram negative bacilli, but no classical Michaelis-Gutmann bodies. The clinical and pathological findings and criteria for the diagnosis of malakoplakia are discussed.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 1992

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References

Azabeh, B., Ardehali, S. (1983) Malakoplakia of the middle ear. Histopathology, 7: 129134.CrossRefGoogle Scholar
Buckley, C. H., Fox, H. (1980) Histiocytic endometritis. Histopathology, 4: 105109.CrossRefGoogle ScholarPubMed
Colby, T. V. (1978) Malakoplakia. Two unusual cases which presented diagnostic problems. American Journal of Surgical Pathology, 2: 377381.Google Scholar
Dale, J. C, Robinson, R. A. (1988) Malakoplakia of the parotid gland. Journal of Laryngology and Otology, 102: 737740.CrossRefGoogle ScholarPubMed
Gabrielides, G. G., Schimer, F., Schwartz, S. (1981) Malakoplakia of the larynx. Pathology, Research and Practice, 172: 5357.CrossRefGoogle ScholarPubMed
Garrett, I. R., McClure, J. (1982) Renal malakoplakia. Experimental production and evidence of a link with interstitial megalocytic nephritis. Journal of Pathology, 136: 111122.CrossRefGoogle ScholarPubMed
Gupta, R. K., Schuster, R. A., Christian, W. D. (1972) Autopsy findings in a unique case of malakoplakia. A cytoimmunohistochemical study of Michaelis-Gutmann bodies. Archives of Pathology, 93: 4254.Google Scholar
Kalfayan, B., Seager, G. M. (1982) Malakoplakia of the palatine tonsil. American Journal of Clinical Pathology, 78: 390394.CrossRefGoogle ScholarPubMed
Kelly, D. R., Murad, T. M. (1981) Megalocytic interstitial nephritis, xanthogranulomatous pyelonephritis and malakoplakia. American Journal of Clinical Pathology, 75: 333344.CrossRefGoogle ScholarPubMed
Lewin, K. J., Harell, G. S., Lee, A. S., Crowley, L. G. (1974) Malakoplakia. An electron microscopic study: demonstration of bacilliform organisms in malakoplakic macrophages. Gastroenterology, 66: 2845.Google Scholar
Lewin, K. J., Fair, W. R., Steigbigel, R. T, Winberg, C. D., Droller, M. J. (1976) Clinical and laboratory studies into the pathogenesis of malakoplakia. Journal of Clinical Pathology, 29: 354363.CrossRefGoogle Scholar
Lou, T. Y., Teplitz, C. (1973) Ultrastructural morphogenesis of malakoplakia and so-called Michaelis-Gutmann bodies. Laboratory Investigation, 28: 390395.Google Scholar
Lou, T. Y., Teplitz, C. (1974) Malakoplakia, pathogenesis and ultrastructural morphogenesis: a problem of altered macrophage (phagolysosomal) response. Human Pathology, 5: 191195.CrossRefGoogle ScholarPubMed
Love, B. B., Stanford, H. S., Jones, B. (1985) Malakoplakia of the tongue base. A case report. Journal of Otolaryngology, 14(3): 179182.Google Scholar
McClure, J. (1983) Malakoplakia. Journal of pathology, 140: 275330.CrossRefGoogle ScholarPubMed
McClure, J., Cameron, C. H. S., Garrett, R. G. (1981) The ultrastructural features of malakoplakia. Journal of Pathology, 134: 1325.CrossRefGoogle ScholarPubMed
McCormick, K., Timme, A. H. (1982) Malakoplakia of the nasopharynx associated with carcinoma. Journal of Laryngology and Otology, 96: 737742.CrossRefGoogle ScholarPubMed
Nayar, R. C, Garg, I., Alapatt, J. J. (1991) Malakoplakia of the termporal bone in a nine-month-old infant. Journal of laryngology and Otology, 105: 568570.CrossRefGoogle Scholar
Nistal, M., Regadera, J., Razquin, S., Paniagua, R., Gavilan, J. (1985) Malakoplakia of the maxillary sinus. Annals of Otology, Rhinology and Laryngology, 94: 117120.CrossRefGoogle ScholarPubMed
Qualman, S. J., Gupta, P. K., Mendelsohn, G. (1984) Intracellular escerichia coli in urinary Malakoplakia: a reservoir of infection and its therapeutic implications. American Journal of Clinical Pathology, 81: 3542.CrossRefGoogle Scholar
Ravel, R. (1967) Megalocytic interstitial nephritis. An entity probably related to Malakoplakia. American Journal of Clinical Pathology, 47: 781789.CrossRefGoogle ScholarPubMed
Rywlin, A. M., Ravel, R., Hurwitz, A. (1969) Malakoplakia of the colon. American Journal of Digestive diseases, 14: 491499.CrossRefGoogle ScholarPubMed
Schreiber, A. G., Maderazo, E. G. (1978) Leucocyte function in Malakoplakia. Archives of Pathology and Laboratory Medicine, 102: 534537.Google ScholarPubMed
Sencer, O., Sencer, H., Uluoglu, O., Torunoglu, M., Tatlicioglu, E. (1979) Malakoplakia of the skin. Ultrastructure and quantitative X-ray microanalysis of Michaelis-Gutmann bodies. Archives of Pathology and Laboratory Medicine, 103: 446450.Google Scholar
Smith, B. H. (1965) Malakoplakia of the urinary tract. American Journal of Clinical Pathology, 43: 409417.Google Scholar
Thorning, D., Vracko, R. (1975) Malakoplakia. Defect in digestion of phagocytosed material due to impaired vacuolar acidification. Archives of Pathology, 99: 456460.Google Scholar