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Non-surgical organ preservation in laryngeal and hypopharyngeal cancers: an audit from the clinic

Published online by Cambridge University Press:  09 June 2022

S Sood ,
S Sinha ,
A Balaji ,
S R Mundhe ,
N Mummudi ,
A Budrukkar ,
M Swain ,
K Prabash ,
V Noronha  and
A Joshi
...Show all authors
S Sood
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
S Sinha
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
A Balaji
Affiliation:
Department of Speech and Therapy, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
S R Mundhe
Affiliation:
Department of Radiation Oncology, Krupamayi Cancer Hospital, Aurangabad, India
N Mummudi
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
A Budrukkar
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
M Swain
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
K Prabash
Affiliation:
Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
V Noronha
Affiliation:
Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
A Joshi
Affiliation:
Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
V Patil
Affiliation:
Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
S G Laskar*
Affiliation:
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
*
Author for correspondence: Dr S Laskar, Department of Radiation Oncology and Head and Neck Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute, Parel, Mumbai 400012, India E-mail: sarbanilaskar@gmail.com
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Abstract

Background

There is increasing concern regarding efficacy of organ preservation protocol in laryngeal and hypopharyngeal cancers.

Method

This study retrospectively assessed disease-related and functional outcomes of 191 patients with non-metastatic laryngeal or hypopharyngeal squamous cell carcinoma treated with curative intent (radiotherapy with or without chemotherapy).

Results

Seventy-six patients (39.8 per cent) had a primary cancer in the larynx, and 115 patients (60.2 per cent) had a primary cancer in the hypopharynx. The median follow up was 39 months. The 3-year time to progression, overall survival, local control and laryngectomy free survival was 56.2 per cent, 76.3 per cent, 73.2 per cent and 67.2 per cent, respectively. At the time of analysis, 83 patients (43.5 per cent) were alive and disease free at their last follow up and did not require tube feeding or tracheostomy. The laryngo-oesophageal dysfunction-free survival was 61 per cent at 3 years.

Conclusion

Organ conservation protocols remain the standard of treatment in appropriately selected patients with laryngeal and hypopharyngeal cancers.

Keywords

LarynxHypopharynxOrgan Preservation
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 4 , April 2023 , pp. 448 - 454
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr S Laskar takes responsibility for the integrity of the content of the paper

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