Hostname: page-component-77c89778f8-7drxs Total loading time: 0 Render date: 2024-07-18T04:43:39.368Z Has data issue: false hasContentIssue false
  • English
  • Français

Nasal extranodal natural killer T cell lymphoma: an atypical presentation

Published online by Cambridge University Press:  07 July 2011

A Sharma ,
M Dandekar ,
S Deshmukh  and
J Dabholkar
A Sharma*
Affiliation:
Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, King Edward VII Memorial Hospital, Mumbai, India
M Dandekar
Affiliation:
Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, King Edward VII Memorial Hospital, Mumbai, India
S Deshmukh
Affiliation:
Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, King Edward VII Memorial Hospital, Mumbai, India
J Dabholkar
Affiliation:
Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, King Edward VII Memorial Hospital, Mumbai, India
*
Address for correspondence: Dr Arpit Sharma, Assistant Professor, Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, KEM Hospital, Parel, Mumbai 400012, India Fax: +91 22 24142503, E-mail: dr_arpit_sharma@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We report two cases of nasal natural killer T cell lymphoma which presented atypically following surgical intervention.

Case report:

Two patients with a previous history of endoscopic nasal surgery presented with progressive facial swelling and necrosis. The histology of several nasal biopsies was suggestive of acute, necrotising inflammation. Considering these patients' midline destruction of the nose and face, and their inconclusive biopsies, immunohistochemical studies were undertaken, enabling the diagnosis of peripheral natural killer T cell lymphoma.

Conclusion:

Natural killer T cell lymphoma of the sinonasal tract is an important differential diagnosis of destructive lesions of the nose and midface. The definitive diagnosis is often delayed. Hence, this tumour should be considered in patients with atypical presentations of acute inflammation following surgical intervention; such patients should be thoroughly investigated. Early immunohistochemical investigation is needed to enable prompt diagnosis in suspicious cases.

Keywords

Paranasal SinusesImmunohistochemistryPathologyLymphoma, T Cell
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 11 , November 2011 , pp. 1181 - 1184
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Chen, HH, Fong, L, Su, IJ, Ting, LL, Hong, RL, Leung, HW. Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T cell lymphoma: a retrospective analysis covering a 34 year period. Radiother Oncol 1996;38:1–6CrossRefGoogle ScholarPubMed
2Patel, V, Mahajan, S, Kharkar, V, Khopkar, U. Nasal extranodal T cell lymphoma presenting as a perforating palatal ulcer: a diagnostic challenge. Indian J Dermatol 2006;72:218–21Google ScholarPubMed
3Chim, CS, Ooi, GC, Shek, TWH, Liang, R, Kwong, YL. Lethal midline granuloma revisited: nasal T/NK cell lymphoma. J Clin Oncol 1999;17:1322–5CrossRefGoogle Scholar
4Rudiger, T, Weisenburger, DD, Anderson, JR, Armitage, JO, Diebold, J, MacLennan, KA et al. Peripheral T cell lymphoma (excluding anaplastic large cell lymphoma): results from non Hodgkin's lymphoma classification project. Ann Oncol 2002;13:140–9CrossRefGoogle ScholarPubMed
5Gadd, MA, Hansbrough, JF, Hoyt, DB, Ozkan, N. Defective T cell surface antigen expression after mitogen stimulation. An index of lymphocyte dysfunction with controlled murine injury. Ann Surg 1989;209:112–18CrossRefGoogle ScholarPubMed
6Lee, HJ, Im, JG, Goo, JM, Kim, KW, Choi, BI, Chang, KH et al. Peripheral T cell lymphoma: spectrum of imaging findings with clinical and pathologic features. Radiographics 2003;23:7–26CrossRefGoogle ScholarPubMed
7Armitage, JO. Management of patients with peripheral T cell lymphoma. Haematol Rep 2006;2:15–18Google Scholar