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Expression of EGF, EGFR and PCNA in laryngeal lesions

Published online by Cambridge University Press:  29 June 2007

Q. H. Wen ,
T. Nishimura ,
T. Miwa ,
I. Nagayama  and
M. Furukawa
Q. H. Wen*
Affiliation:
Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan.
T. Nishimura
Affiliation:
Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan.
T. Miwa
Affiliation:
Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan.
I. Nagayama
Affiliation:
Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan.
M. Furukawa
Affiliation:
Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan.
*
Dr Q. H. Wen, Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan. Fax: 00-81-762-344265
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Abstract

The expression of EGF/EGFR in 47 laryngeal surgical specimens from 44 patients was examined. PCNA analysis as an index of proliferating cells was also performed in 32 cases of laryngeal cancer, six cases of pre-cancerous lesions and nine cases of normal laryngeal mucosa. EGFR failed to show a significant correlation with tumour behaviour, but EGF expression was statistically significantly higher in malignant (SCC) than in non-malignant tissues (pre-cancerous and normal tissues) (p<0.006), and PCNA also showed a statistically significant difference (p<0.016) between the two. In malignant tissues when EGF/EGFR in ‘double-positive’ and ‘double-negative’ cases was compared, a statistically significant difference in PCNA was found (p<0.029); but this was not seen in non-malignant tissues. Our results support the hypothesis that an autocrine mechanism exists in laryngeal cancer and in this mechanism EGF may play an important role in tumour progression, especially when EGFR is overexpressed.

Keywords

Laryngeal neoplasmsImmunohistochemistry
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 7 , July 1995 , pp. 630 - 636
Copyright
Copyright © JLO (1984) Limited 1995

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