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The effects of peracetic acid solution on the treatment of otomycosis in an animal model: a new antifungal drug?

Published online by Cambridge University Press:  15 December 2022

S Nemati ,
M Akbarpour ,
E Lotfali ,
R Nosrati ,
E Rafiee  and
N Zebardast Open the ORCID record for N Zebardast [Opens in a new window]
S Nemati
Affiliation:
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M Akbarpour
Affiliation:
Otorhinolaryngology Research Center, Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
E Lotfali
Affiliation:
Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
R Nosrati
Affiliation:
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
E Rafiee
Affiliation:
Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran
N Zebardast*
Affiliation:
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*
Author for correspondence: Dr N Zebardast, Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, 6th Kilometer of Rasht-Tehran Highway, Rasht 41937-1311, Iran E-mail: nszebardast@gmail.com
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Abstract

Objective

This study aimed to investigate the therapeutic effects of 1 per cent and 0.01 per cent peracetic acid as an antifungal agent in animal otomycosis.

Method

After creating a superficial scratch in the external auditory canal of guinea pigs, a suspension of Aspergillus niger, Aspergillus fumigatus and candida were inoculated into the ears of the animals. After otomycosis, the effect of 1 per cent or 0.01 per cent peracetic acid on otomycosis was evaluated by otomicroscopy and culture at 10 days post-treatment and compared with 2 per cent acetic acid as the control.

Results

A 10-day treatment with 1 per cent peracetic acid and 2 per cent acetic acid (control) showed normal otomicroscopy and negative cultures compared with 0.01 per cent peracetic acid. Drug sedimentation or other side effects in the external auditory canal or tympanic membrane were not observed during treatment with peracetic acid.

Conclusion

The findings of this study confirm that the treatment of otomycosis with 1 per cent peracetic acid in an animal model is beneficial and may be a novel therapeutic treatment for otomycosis.

Keywords

OtomycosisPeracetic AcidAcetic AcidGuinea Pigs
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 7 , July 2023 , pp. 799 - 803
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr N Zebardast takes responsibility for the integrity of the content of the paper

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