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Creutzfeldt–Jakob disease and ENT

Published online by Cambridge University Press:  22 October 2013

N Sethi ,
J Kane  and
L Condon
N Sethi*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Mid Yorkshire NHS Trust, Pinderfields Hospital, Wakefield, UK
J Kane
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Mid Yorkshire NHS Trust, Pinderfields Hospital, Wakefield, UK
L Condon
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Mid Yorkshire NHS Trust, Pinderfields Hospital, Wakefield, UK
*
Address for correspondence: Mr Neeraj Sethi, 3 Victoria St, Leeds LS7 4PA, UK Fax: +44 (0)113 269 8885 E-mail: neerajsethi@doctors.org.uk
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Abstract

Objective:

This review addresses Creutzfeldt–Jakob disease in the context of ENT, and aims to summarise the relevant history, pathophysiology and implications for contemporary practice.

Overview:

Creutzfeldt–Jakob disease is a rare, fatal, neurodegenerative disorder. It is a prion disease with four different subtypes that can only be definitively diagnosed post-mortem. The main implications for the ENT surgeon lie in the risk of iatrogenic transmission. The three facets of assessing individual patient risk are: patient history; tissue infectivity; and procedure infectivity.

Conclusion:

This is a controversial area in medicine, and ENT in particular. This review highlights a clinically applicable approach for everyday use.

Keywords

Creutzfeldt-Jakob DiseaseTransmissible Spongiform EncephalopathiesPrionsOtorhinolaryngology
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 11 , November 2013 , pp. 1050 - 1055
Copyright
Copyright © JLO (1984) Limited 2013 

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