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Assessment of nasal mucociliary activity in patients with Behçet's disease

Published online by Cambridge University Press:  04 February 2016

I Ozbay ,
C Kucur ,
F Temİzturk ,
Y Ozkan ,
C Kahraman  and
F Oghan
I Ozbay*
Affiliation:
Department of ORL, Dumlupinar University, Kutahya, Turkey
C Kucur
Affiliation:
Department of ORL, Dumlupinar University, Kutahya, Turkey
F Temİzturk
Affiliation:
Department of Physical Therapy and Rehabilitation, Dumlupinar University, Kutahya, Turkey
Y Ozkan
Affiliation:
Department of Physical Therapy and Rehabilitation, Dumlupinar University, Kutahya, Turkey
C Kahraman
Affiliation:
Department of Internal Medicine, Dumlupinar University, Kutahya, Turkey
F Oghan
Affiliation:
Department of ORL, Dumlupinar University, Kutahya, Turkey
*
Address for correspondence: Dr Isa Ozbay, Department of Otolaryngology, Medicine Faculty of Dumlupinar University, Kutahya, Turkey Fax: +90 274 231 6673 E-mail: isaozbay@gmail.com
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Abstract

Objective:

To investigate nasal mucociliary clearance in patients with Behçet's disease.

Methods:

Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the International Study Group for Behçet's Disease, and 30 healthy individuals were recruited. In both groups, individuals with conditions that could affect nasal mucociliary clearance were excluded. Nasal mucociliary clearance time was evaluated using saccharin tests. The time between placement of a saccharin tablet and the tasting of the saccharin was measured and recorded as the saccharin clearance time.

Results:

The mean nasal mucociliary clearance time was significantly longer in the Behçet's disease patients than in the control subjects (p < 0.001). Furthermore, there was a positive correlation between Behçet's disease duration and nasal mucociliary clearance time (p < 0.001, r = 0.882).

Conclusion:

The results suggest that nasal mucociliary clearance time is longer in Behçet's disease patients than in control subjects, and is positively correlated with disease duration.

Keywords

Nasal MucosaBehçet DiseaseSaccharin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 4 , April 2016 , pp. 348 - 351
Copyright
Copyright © JLO (1984) Limited 2016 

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References

1Behçet, H. Oral relapsing, aphthous ulcers of the mouth, eye and genitalia caused by a virus [in German]. Dermatol Wochenschr 1937;105:1152–7Google Scholar
2Webb, CJ, Moots, RJ, Swift, AC. Ear, nose and throat manifestations of Behçet's disease: a review. J Laryngol Otol 2008;122:1279–83CrossRefGoogle ScholarPubMed
3Uysal, IO, Gokakın, AK, Karakus, CF, Deveci, K, Hasbek, Z, Sancakdar, E. Evaluation of nasal mucociliary activity in iatrogenic hypothyroidism. Eur Arch Otorhinolaryngol 2013;270:3075–8Google Scholar
4Asai, K, Haruna, S, Otori, N, Yanagi, K, Fukami, M, Moriyama, H. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope 2000;110:117–22Google Scholar
5Lale, AM, Mason, JD, Jones, NS. Mucociliary transport and its assessment: a review. Clin Otolaryngol 1998;23:388–96CrossRefGoogle ScholarPubMed
6Habesoglu, M, Demir, K, Yumusakhuylu, AC, Yilmaz, AS, Oysu, C. Does passive smoking have an effect on nasal mucociliary clearance? Otolaryngol Head Neck Surg 2012;147:152–6CrossRefGoogle ScholarPubMed
7Veyseller, B, Dogan, R, Ozücer, B, Aksoy, F, Meric, A, Su, O et al. Olfactory function and nasal manifestations of Behçet's disease. Auris Nasus Larynx 2014;41:185–9CrossRefGoogle ScholarPubMed
8Verim, A, Cebeci, F, Baser, E, Calim, ÖF, Kadioğlu, D, Kocagöz, GD. Prevalence of chronic rhinosinusitis in the setting of Behçet disease. J Craniofac Surg 2015;26:186–90Google Scholar
9International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990;335:1078–80Google Scholar
10O'Neill, TW, Rigby, AS, Silman, AJ, Barnes, C. Validation of the International Study Group criteria for Behçet's disease. Br J Rheumatol 1994;33:115–17CrossRefGoogle Scholar
11Morales-Angulo, C, Vergara Pastrana, S, Obeso-Agüera, S, Acle, L, Gonzalez-Gay, MA. Otorhinolaryngological manifestations in patients with Behçet disease [in Spanish]. Acta Otorrinolaringol Esp 2014;65:15–21Google Scholar
12Shahram, F, Zarandy, MM, Ibrahim, A, Ziaie, N, Saidi, M, Nabaei, B et al. Nasal mucosal involvement in Behçet disease: a study of its incidence and characteristics in 400 patients. Ear Nose Throat J 2010;89:30–3Google Scholar
13Soylu Özler, G, Akbay, E, Akkoca, AN, Karapınar, OS, Şimşek, GÖ. Does menopause effect nasal mucociliary clearance time? Eur Arch Otorhinolaryngol 2015;272:363–6Google Scholar
14Sun, SS, Hsieh, JF, Tsai, SC, Ho, YJ, Kao, CH. The role of rhinoscintigraphy in the evaluation of nasal mucociliary clearance function in patients with sinusitis. Nucl Med Commun 2000;21:1029–32Google Scholar
15Sakakura, Y, Ukai, K, Majima, Y, Murai, S, Harada, T, Miyoshi, Y. Nasal mucociliary clearance under various conditions. Acta Otolaryngol 1983;96:651–4CrossRefGoogle ScholarPubMed
16Maurizi, M, Paludetti, G, Todisco, T, Almdori, G, Ottaviani, F, Zappone, C. Ciliary ultrastructure and nasal mucociliary clearance in chronic and allergic rhinitis. Rhinology 1984;22:233–40Google ScholarPubMed
17Wanner, A. Allergic mucociliary dysfunction. Laryngoscope 1983;93:68–70Google Scholar
18Di Giuda, D, Galli, J, Calcagni, ML, Corina, L, Paludetti, G, Ottaviani, F et al. Rhinoscintigraphy: a simple radioisotope technique to study the mucociliary system. Clin Nucl Med 2000;25:127–30Google Scholar
19Nuutinen, J. Asymmetry in the nasal mucociliary transport rate. Laryngoscope 1996;106:1424–8Google Scholar
20Soane, RJ, Carney, AS, Jones, NS, Frier, M, Perkins, AC, Davis, SS et al. The effect of nasal cycle on mucociliary clearance. Clin Otolaryngol 2001;26:9–15CrossRefGoogle ScholarPubMed
21Polat, C, Dostbil, Z. Evaluation of the nasal mucociliary transport rate by rhinoscintigraphy before and after surgery in patients with deviated nasal septum. Eur Arch Otorhinolaryngol 2010;267:529–35Google Scholar