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Antimicrobial Prophylaxis for Major head and neck cancer surgery with piperacillin and ornidazole

Published online by Cambridge University Press:  29 June 2007

L. Dominici ,
R. Gondret ,
V. Broc ,
S. Dubos ,
M. Viallard  and
P. Deligne
L. Dominici*
Affiliation:
Paris, France
R. Gondret
Affiliation:
Paris, France
V. Broc
Affiliation:
Paris, France
S. Dubos
Affiliation:
Paris, France
M. Viallard
Affiliation:
Paris, France
P. Deligne
Affiliation:
Paris, France
*
Docteur Lionel Dominici, Departement d'Anesthesie, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France.
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Abstract

A prospective study in 53 eligible patients, undergoing major head and neck cancer surgery was carried out to assess the combination of an ureido penicillin, piperacillin with a nitro imidazole agent, ornidazole, in order to prevent post-operative general and wound infections. Both antibiotics were administered for five days. Each patient had piperacillin 4 gm every eight hours and ornidazole 1 gm every 24 hours.

The overall rate of infections was 13.2 per cent (n = 7), with 3.8 per cent (n = 2) wound infections and 11.3 per cent (n = 6) general infections (one patient presented both complications).

There was no wound infection in the total surgery group (n = 12). General infections who only consisted of pneumonias were respectively 12.2 per cent (n - 5) in the group with partial procedures (n = 41) and 8.3 per cent (n = 1) in the total surgery group.

This antibioprophylaxis can be recommended in major oncological neck surgery, specially in the case of partial procedures.

Keywords

AntibioticscombinedPiperacillinOrnidazoleHead and neck neoplasmsSurgery
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 5 , May 1992 , pp. 409 - 411
Copyright
Copyright © JLO (1984) Limited 1992

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