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Adrenal suppression with intranasal betamethasone drops

Published online by Cambridge University Press:  29 June 2007

M. D. Flynn ,
P. Beasley  and
J. E. Tooke
M. D. Flynn*
Affiliation:
Departments of Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter. EX2 5DW.
P. Beasley
Affiliation:
Department of Otolaryngology, Royal Devon and Exeter Hospital, Barrack Road, Exeter. EX2 5DW.
J. E. Tooke
Affiliation:
Departments of Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter. EX2 5DW.
*
Department of Medicine, Prince Phillip Hospital, Llanelli, Dyfed, SA14 8QF. Fax: 0554 772271
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Abstract

Intranasal betamethasone sodium phosphate drops (Betnesol) are frequently used to relieve nasal congestion due to polyposis. We report a case of significant hypothalamic-pituitary-adrenal suppression secondary to the long-term use of intranasal betamethasone drops. This case emphasizes that the topical application of potent corticosteroids may produce systemic effects.

Keywords

Adrenal gland hypofunctionBetamethasoneNasal polyps
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 9 , September 1992 , pp. 827 - 828
Copyright
Copyright © JLO (1984) Limited 1992

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References

Ali, N. J., Capewell, S., Ward, M. J. (1991) Bone turnover during high dose inhaled corticosteroid treatment. Thorax, 46: 160–164.CrossRefGoogle ScholarPubMed
Chalton, R., MacKay, I., Wilson, R., Cole, P. (1985) Double blind, placebo controlled trial of betamethasone nasal drops for nasal polyposis. British Medical Journal, 291: 788.CrossRefGoogle ScholarPubMed
Clayton, R. (1989) Diagnosis of adrenal insufficiency. British Medical Journal, 298: 271–272.CrossRefGoogle ScholarPubMed
Dixon, R. B., Christy, N. P. (1980) On various forms of corticosteroid withdrawal syndrome. Americanht Journal of Medicine, 68: 224–230.CrossRefGoogle ScholarPubMed
Drug and Therapeutics Bulletin (1989) 27: 69–71.CrossRefGoogle Scholar
Harris, D. M., Martin, L. E., Harrison, C, Jack, D. (1974) The effect of intranasal beclomethasone dipropionate on adrenal function. Clinical Allergy, 4: 291–294.CrossRefGoogle ScholarPubMed
Kruszynska, Y. T.Greenstone, M.Home, P. D., Cooke, N. J. (1987) Effect of high dose inhaled beclomethasone dipropionate on carbohydrate and lipid metabolism in normal subjects. Thorax, 42: 881–884.CrossRefGoogle ScholarPubMed
Norman, P. S., Winkenwerder, W. L., Agbayni, B. R.Migeon, C. J. (1967) Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever. Journal of Allergy, 40: 57–61.CrossRefGoogle ScholarPubMed
Pedersen, S., Fugslang, C. (1988) Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: a comparison of budesonide and beclomethasone. European Respiratory Journal, 1: 433–435.CrossRefGoogle ScholarPubMed
Reynolds, J. E. F. (1989) Corticosteroids. In Martindale. The extra Pharmacopoeia. 29th Edition. Pharmaceutical Press, London, p. 872–902.Google Scholar
Ryrfeldt, A., Andersson, P., Edsbacker, S., Tonnesson, M., Davies, D., Pauwels, R. (1982) Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. European Journal of Respiratory Diseases, 122(suppl): 86–95.Google ScholarPubMed
Sherman, B., Weinberger, M., Chen-Walden, H., Wendt, H. (1982) Further studies on the effect of inhaled glucocorticoids on the pituitary-adrenal function in healthy adults. Journal of Allergy and Clinical Immunology, 69: 208–212.CrossRefGoogle ScholarPubMed
Smith, M. J., Hodson, M. E. (1983) Effects of long term inhaled high dose beclomethasone dipropionate on adrenal function. Thorax, 8: 676–681.CrossRefGoogle Scholar
Sorkin, S., Warren, D. (1986) Probable adrenal suppression from intranasal beclomethasone. Journal of Family Practice, 22: 449–450.Google ScholarPubMed
Stevens, D. J. (1988) Cushing's syndrome due to abuse of betamethasone nasal drops. Journal of Laryngology and Otology, 102: 219–221.CrossRefGoogle ScholarPubMed