Hostname: page-component-7479d7b7d-k7p5g Total loading time: 0 Render date: 2024-07-12T04:21:21.859Z Has data issue: false hasContentIssue false
  • English
  • Français

Spindle cell carcinoma of the parotid gland

Published online by Cambridge University Press:  29 June 2007

Toshio Ishibashi  and
Hiroshi Hojo
Toshio Ishibashi*
Affiliation:
Department of Otolaryngology, Kanto Teishin Hospital, Tokyo, Japan.
Hiroshi Hojo
Affiliation:
Department of Pathology, Fukushima Medical College, Fukushima, Japan.
*
Dr Toshio Ishibashi, Department of Otolaryngology, Kanto Teishin Hospital, 5-9-22, Higashi-Gotanda, Shinagawa-ku, Tokyo 141, Japan. Fax: 3-3448-6617
Get access Rights & Permissions [Opens in a new window]

Abstract

Spindle cell carcinomas of the salivary gland are extremely rare, with only a few cases having been previously reported. We present a 55-year-old man with a rapidly enlarging mass in the left parotid gland. Despite radical surgery, the tumour recurred, and led to death 11 months later. Histopathologically, the tumour was composed of two components, a squamous cell carcinoma component and a spindle cell sarcomatoid component. A diagnosis of primary spindle cell carcinoma of the parotid gland was made. Immunohistochemical studies revealed keratin positivity and vimentin negativity in the squamous cell carcinoma component: the spindle cell sarcomatoid component was positive for vimentin and negative for keratin, but showed focal positivity for epithelial membrane antigen. The origin of the sarcomatoid component and the differential diagnosis from malignant mixed tumours are discussed.

Keywords

Salivary gland neoplasmsParotid glandCarcinomaspindle cellImmunohistochemistry
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 7 , July 1995 , pp. 683 - 686
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addis, B. J., Corrin, B. (1985) Pulmonary blastoma, carcinosarcoma and spindle cell carcinoma: an immunohistochemical study of keratin intermediate filaments. Journal of Pathology 147: 291–301.CrossRefGoogle ScholarPubMed
Auclair, P. L., Langloss, L. M., Weiss, S. W. (1986) Sarcomas and sarcomatoid neoplasms of the major salivary gland regions. Cancer 58: 1305–1315.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Bansal, M., Kaneko, M, Gordon, R E. (1982) Carcinosarcoma and separate carcinoid tumour of the stomach. Cancer 50: 1876–1881.3.0.CO;2-7>CrossRefGoogle Scholar
Batsakis, J. G. (1979) Tumours of the Head and Neck: Clinical and Pathological Considerations 2nd Edition. Williams and Wilkins Co., Baltimore, pp 26–30.Google Scholar
Batsakis, J. G., Rice, D. H., Howard, D. R. (1982) The pathology of the head and neck tumours: spindle cell lesions (sarcomatoid carcinomas, nodular fascilitis, and fibrosarcoma) of the aerodigestive tracts, part 14. Head and Neck Surgery 4: 499–513.CrossRefGoogle Scholar
Claessen, M., Mathias, E. (1921) Beitrage zur Lehre vom carcinosarkom. Bruns, Beitrage zur Klinischen Chirurgie 123: 584–599.Google Scholar
Kuhajda, F. P., Sun, T. X, Mendelsohn, G. (1983) Polypoid squamous carcinoma of the esophagus. A case report with immunostaining for keratin. American Journal of Surgical Pathology 7: 495–499.CrossRefGoogle ScholarPubMed
Leader, M., Collins, M., Patel, J. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology 11: 63–72.CrossRefGoogle ScholarPubMed
Leventon, G. S., Harry, L. E. (1981) Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck. A clinicopathologic study of 20 cases. Cancer 48: 994–1003.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Love, G. L., Sarma, D. P. (1986) Spindle cell mucoepidermoid carcinoma of the submandibular gland. Journal of Surgical Oncology 31: 66–68.CrossRefGoogle Scholar
Ogawa, K., Kim, Y. C., Nagashima, Y. (1987) expression of epithelial markers in sarcomatoid carcinoma: an immunohistochemical study. Histopathology 11: 511–522.CrossRefGoogle ScholarPubMed
Stoler, A. B., Stenback, F, Balmain, A. (1993) The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. Journal of Cell Biology 122: 1103–1117.CrossRefGoogle ScholarPubMed
Weidner, N. (1987) Sarcomatoid carcinoma of the upper aerodigestive tract. Seminars in diagnostic pathology 4: 157–168.Google ScholarPubMed