Hostname: page-component-77c89778f8-vpsfw Total loading time: 0 Render date: 2024-07-20T04:19:25.007Z Has data issue: false hasContentIssue false
  • English
  • Français

Flunarizine in the treatment of vertigo

Published online by Cambridge University Press:  29 June 2007

L. Wouters ,
W. Amery  and
G. Towse
L. Wouters
Affiliation:
Beerse, Belgium and Eastleigh, U.K. Janssen Pharmaceutica N. V., Research Laboratoies, B-2340 Beerse, Belgium. Address for reprint: L. Wouters, D.V.M. Janssen Pharmaceutica N. V., Research Laboratoies, B-2340 Beerse, Belgium.
W. Amery
Affiliation:
Beerse, Belgium and Eastleigh, U.K. Janssen Pharmaceutica N. V., Research Laboratoies, B-2340 Beerse, Belgium.
G. Towse
Affiliation:
Beerse, Belgium and Eastleigh, U.K. Warner-Lambert (U.K.) Ltd., Clinical Unit pf Biometrics. Woodside Avenue, Eastleigh. Hants. United Kingdom.
Get access Rights & Permissions [Opens in a new window]

Abstract

Experience with flunarizine, a selective calcium-entry blocker, in the treatment of dizziness is reviewed. Clinical efficacy was predicted in pharmacological studies both in rabbits and humans: torsion swing or caloric induced nystagmus were significantly suppressed by flunarizine. Open therapeutic findings, using clinical and electronystagmographic or audiographic assessments as well, showed that flunarizine is of benefit to patients with vertigo of labyrinthine as well as of cerebrovascular origin. These results were confirmed in double-blind controlled trials. Flunarizine, either started with a loading dose gradually decreased thereafter, or given at a fixed 10 mg. dose schedule was proven to produce rapid improvement of dizziness and unsteadiness and to be tolerated very well.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 97 , Issue 8 , August 1983 , pp. 697 - 704
Copyright
Copyright © JLO (1984) Limited 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Boniver, R. (1978) Vertigo particularly of vascular origin, treated with flunarizine (R 14 950). Arzneimittel-Forschung, 28: 1800.Google ScholarPubMed
Bordes, L. R. (1973) Expertise clinique du ‘F.F. 14 950’ (flunarizine) comprimés en oto-rhino-laryngologic (Unpublished report).Google Scholar
Domschky, K., Nelson, M., Dammhayn, B. and Terjung, E. (1977) Flunarizin bei Patienten mit zerebralen und peripheren Mangeldurchblutung multizentrische doppelblind Studie. Der bedingung der ärztlichen Praxis. Medizinische Welt, 28: 1062.Google Scholar
Eichstetter, F. (1976) Double-blind study of flunarizine versus placebo in patients with cerebral circulatory disturbances. Janssen Research Products Information Service, Clinical Research Report No. 15.Google Scholar
Hofferberth, B. (1980) Die Anwendung von Flunarizin bei Patienten mit vertebrobasilärer Insuffizienz. Erfahrungen aus einer Pilotstudie (vorläufige Mitteilung). Arzrwimittel-Forschung, 30: 1817.Google Scholar
Janssen Pharmaceutica (1981) A multicentre evaluation of flunarizine in dizziness associated with balance disorders (Unpublished report).Google Scholar
Mangabeira-Albernaz, P. L., Malavasi, Gananca M., Ferreira, Novo N. and Rodrigues de Paiva, E. (1978) Flunarizine and cinnarizine as vestibular depressants. A statistical study. Journal of Oto-Rhino-Laryngology, 40: 92.Google ScholarPubMed
Materna, F. (1981) Erfahrungen mit Flunarizin bei der Behandlung von otoneurologischen Symptomen. Medizinische Welt, 32: 1157.Google Scholar
Müler, P. and Blum, D. (1980) Essai thérapeutique de la flunarizine dans la sphere ORL. Etude ouverte (Unpublished report).Google Scholar
Müler, P. and Blum, D. (1981) Efficacité de la flunarizine dans le traitement des vertiges, acouphenes et hypoacousie de perception. Etude en double aveugle (Unpublished report).Google Scholar
Nelson, M., Dewitz, G., Dom, J., and HoeriG, Ch. (1978) Prüfung der Wirksamkeit von Sibelium (Flunarizin) bei Durchblutungsstörungen. Medizinische Welt, 29: 1175.Google Scholar
Oosterveld, W. J. (1974 a) Vestibular pharmacology of flunarizine compared to that of cinnarizine. Oto-Rhino-Laryngology, 36: 157.Google ScholarPubMed
Oosterveld, W. J. (1974 b) Pilot evaluation of flunarizine (R 14 950) in vertigo. A double-blind trial. Canadian Journal of Otolaryngology, 3: 284.Google Scholar
Oosterveld, W. J. (1982) Flunarizine in vertigo. A double-blind placebo-controlled cross-over evaluation of a constant-dose schedule. Oto-Rhino-Laryngology, 44: 72.Google ScholarPubMed
Rebello de Mattos, G. (1979) Flunarizine on central circulatory disorders (Unpublished report).Google Scholar
Scherer, H., Schmidtmayer, E. and Hirche, H. (1978) Die Wirkung von Bencyclan, Flunarizin und Naftidrofuryl auf den Nystagmus eines kalorischen Dauerreizes. Laryngologie, Rhinologie, Otologie, 57: 773.Google Scholar
Schwerdtfeger, F. (1978) Gestörte Vestibularfunktion. Ergebnisse mit Flunarizin in einer Zweiphasenprüfung gegen Placeboärztliche Praxis, 30: 451.Google Scholar
Selim, A. (1977) Double-blind study with flunarizine in patients with cerebral and peripheral circulation deficiency. Analysis of the safety data. Janssen Research Products Information Service, Clinical Research Report No. 25.Google Scholar
Staessen, A. J. (1977) Treatment of circulatory disturbances with flunarizine and cinnarizine. A multicentre, double-blind and placebo-controlled evaluation. VASA, 6: 59.Google Scholar
Towse, G. (1980) Cinnarizine—a labyrinthine sedative. Journal of Laryngology and Otology, 94: 1009.CrossRefGoogle ScholarPubMed
Zissis, N. P., Alevizos, V. and Dontas, A. S. (1981) Flunarizine, an inhibitor of Ca+2-induced vascular constriction in geriatric patients. Current Therapeutic Research, 29: 395.Google Scholar