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Eosinophilic granulomatosis with polyangiitis and laryngeal involvement: review of the literature and a cross-sectional prospective experience

Published online by Cambridge University Press:  11 June 2018

V Seccia
Affiliation:
First Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
L Cristofani-Mencacci*
Affiliation:
First Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
I Dallan
Affiliation:
First Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
S Fortunato
Affiliation:
First Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
M L Bartoli
Affiliation:
Respiratory Pathophysiology Unit, Cardio-Thoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
S Sellari-Franceschini
Affiliation:
First Otorhinolaryngology Unit, Department of Neuroscience, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
M Latorre
Affiliation:
Respiratory Pathophysiology Unit, Cardio-Thoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
P L Paggiaro
Affiliation:
Respiratory Pathophysiology Unit, Cardio-Thoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
C Baldini
Affiliation:
Rheumatology Unit, University of Pisa, Italy
*
Address for correspondence: Dr Lodovica Cristofani-Mencacci, First Otorhinolaryngology Unit, Azienda Ospedaliero-Universitaria Pisana, Via Paradisa n.2, 56124, Pisa, Italy Fax: +39 050 997542 E-mail: lodovicacristofani@yahoo.it

Abstract

Background

Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis show variable otorhinolaryngological involvement. Up to 14 per cent of granulomatosis with polyangiitis patients have subglottis involvement; little is known about the laryngeal involvement in eosinophilic granulomatosis with polyangiitis.

Method

A literature review was conducted, together with a prospective cross-sectional analysis of 43 eosinophilic granulomatosis with polyangiitis patients. All patients underwent fibre-optic laryngoscopy with narrow-band imaging, and completed health-related questionnaires.

Results

The literature review showed only two cases of laryngeal involvement in eosinophilic granulomatosis with polyangiitis; in our cohort, no cases of subglottis stenosis were found, but local signs of laryngeal inflammation were present in 72 per cent of cases. Of the patients, 16.2 per cent had a pathological Reflux Finding Score (of 7 or higher).

Conclusion

Laryngeal inflammation in eosinophilic granulomatosis with polyangiitis is frequent. It is possibly due more to local factors than to eosinophilic granulomatosis with polyangiitis itself. However, ENT evaluation is needed to rule out possible subglottis inflammation. These findings are in line with current literature and worthy of confirmation in larger cohorts.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr L Cristofani-Mencacci takes responsibility for the integrity of the content of the paper

References

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