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Bilateral Warthin's tumour of the parotid gland: a 16-year retrospective analysis and systematic review

Published online by Cambridge University Press:  03 November 2023

Zohaib Siddiqui*
Department of ENT, East Kent Hospitals University NHS Trust, Canterbury, UK
Ahaan Gupta
University of Nottingham Medical School, Nottingham, UK
Ronald H K Nam
Aston Medical School, Birmingham, UK
Richard C T Huynh
Newcastle University School of Medicine, Newcastle upon Tyne, UK
Mikaeel Jan
Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA
Keli Dusu
Department of ENT, East Kent Hospitals University NHS Trust, Canterbury, UK
Vikram Dhar
Department of ENT, East Kent Hospitals University NHS Trust, Canterbury, UK
Corresponding author: Zohaib Siddiqui; Email:



Warthin's tumours are the second most common benign parotid tumours in the UK. The World Health Organization states that 5–14 per cent of patients have bilateral Warthin's tumours. This study aimed to: assess the presence of contralateral Warthin's tumours in patients who underwent surgery over the past 16 years at a head and neck unit in England, and perform the first systematic literature review on bilateral Warthin's tumours.


A retrospective analysis was conducted on patients diagnosed with Warthin's tumour based on histology between 2005 and 2020. Additionally, a systematic review (International Prospective Register of Systematic Reviews (‘PROSPERO’) registration number: CRD42022326846) was performed using PubMed and the Cochrane Library.


Among 290 patients diagnosed with Warthin's tumours based on histology following surgery, 24.5 per cent had bilateral Warthin's tumours. The systematic review identified 157 papers, with 14 meeting the inclusion criteria.


This study revealed that 24.5 per cent of patients had bilateral Warthin's tumours, deviating from the suggested range. These findings are of interest to surgeons discussing the disease with patients.

Main Article
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Joint first authors

Zohaib Siddiqui takes responsibility for the integrity of the content of the paper


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