Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-12-04T10:50:41.863Z Has data issue: false hasContentIssue false

Association of p53 expression with second primary tumour development in hypopharyngeal carcinoma

Published online by Cambridge University Press:  08 March 2006

Kenji Hattori
Affiliation:
Departments of Otolaryngology, Osaka University Medical School, Suita, Japan
Hidenori Inohara
Affiliation:
Departments of Otolaryngology, Osaka University Medical School, Suita, Japan
Toru Sawada
Affiliation:
Departments of Otolaryngology, Osaka University Medical School, Suita, Japan
Yuichiro Honjo
Affiliation:
Osaka Teishin Hospital, Osaka, Japan.
Jun-Ichi Yoshida
Affiliation:
Osaka Teishin Hospital, Osaka, Japan.
Takeshi Kubo
Affiliation:
Departments of Otolaryngology, Osaka University Medical School, Suita, Japan

Abstract

Abnormalities of p53 tumour suppressor gene are detected in a diversity of malignancies and play an important role in their pathogenesis. Hypopharyngeal carcinoma is the most morbid among head and neck squamous cell carcinomas because of the high incidence of treatment failures and because a biological marker predictive of the treatment failures remains elusive. The expression of p53 protein in 46 hypopharyngeal squamous cell carcinomas was examined histochemically and p53 immunoreactivity was found in 19 of 46 cases (41.3 per cent). The rate of second primary tumour development was significantly higher in the p53-positive group than in the p53-negative group (p = 0.039), whereas that of tumour recurrence was not significantly different between the two. Moreover, there was no statistically significant difference in either overall or disease-free survival between the p53-positive and -negative groups. These results indicate that although p53 expression significantly correlates with second primary tumour development in patients with hypopharyngeal squamous cell carcinomas, it is not predictive of the clinical outcome.

Type
Research Article
Copyright
Royal Society of Medicine Press Limited 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)