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Parasite antigenaemia and IgG4 antibodies to a filarial protease in an endemic human population in India

Published online by Cambridge University Press:  12 April 2024

M.S. Bal ,
M.K. Beuria ,
N.N. Mandal  and
M.K. Das
M.S. Bal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
M.K. Beuria
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
N.N. Mandal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
M.K. Das*
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
*
*Author for correspondence Fax: 91 0674 301351 E-mail: mkd4@rediffmail.com
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Abstract

Levels of circulating filarial antigen (Og4C3) and IgG4 antibodies to a filarial protease were determined in subjects of Wuchereria bancrofti exposed sera from Orissa, India. In addition to all individuals with antigenaemia (microfilaraemia), IgG4 antibodies were also detected in some individuals without antigenaemia. A 2-year longitudinal follow-up indicated that IgG4 seropositivity in asymptomatic amicrofilaraemics could be a risk factor for acquiring infection (antigenaemia).

Type
Review Article
Information
Journal of Helminthology , Volume 77 , Issue 4 , December 2003 , pp. 287 - 290
Copyright
Copyright © Cambridge University Press 2003

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