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The Metabolism of Trichinosed Rats During the Early Phase of the Disease

Published online by Cambridge University Press:  18 November 2009

W. P. Rogers
W. P. Rogers
Affiliation:
Institute of Agricultural Parasitology, St. Albans.
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Extract

The changes in protein digestion, crude fibre digestion and the chief urinary constituents found in four rats after experimental infection with Trichinella spiralis are detailed.

Diarrhoea and anorexia occurred during the period 8 to 12 days after infection when protein digestion fell to its lowest point. It is suggested that this was due to antiproteases secreted by the adult parasites and to mechanical damage in the intestinal mucosa caused by their movements.

Urinary N rose immediately after infection in “non-resistant” rats. This was followed by a period of decreased N output after which the excretion rate rose steeply.

The urea output also rose immediately after infection in “non-resistant” rats. During the period 4 to 12 days from the time of infection urea excretion fell. Thereafter there was a great increase in its rate of output. Most of these changes have been attributed to toxins elaborated by the adult parasites for massive larval invasion of the tissues probably did not occur till after the experiments were terminated.

Ammonia excretion rose as urinary urea decreased. The fall in urea N was not compensated by the rise in ammonia N + the fall in dietary N intake. The ammonia output returned rapidly to normal suggesting that the excess ammonia was not produced in response to acidosis when the urea excretion rate rose.

Creatine excretion showed a marked fall during the period 4 to 12 days after infection. Urinary creatine and creatinine rose steeply following this period. Possible reasons for these variations are discussed.

Type
Research Papers
Information
Journal of Helminthology , Volume 19 , Issue 3-4 , December 1941 , pp. 87 - 104
Copyright
Copyright © Cambridge University Press 1941

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References

Augustine, D. L., 1936.— “Blood sugar values and the tolerance for dextrose in trichinosis.” Amer. J. Hyg., xxiv (1), 170—176. (W.L. 600a.)Google Scholar
Benedict, S. R., 1914.— “Studies in creatine and creatinine metabolism. II. The estimation of creatine.” J. biol. Chem., xviii, 191. (W.L. 11063.)CrossRefGoogle Scholar
Benedict, S. R. & Nash, T. P., 1921.—“The ammonia content of the blood and its bearing on the mechanism of acid neutralization in the animal organism.” J. biol. Chem., xlviii, 463. (W.L. 11063.)Google Scholar
Benedict, S. R. & Nash, T. P., 1926.— “The site of ammonia formation and the role of vomiting in ammonia elimination.” J. biol. Chem., lxix, 381. (W.L. 11063.)CrossRefGoogle Scholar
Brody, S., Proctor, R. C. & Ashworth, U. S., 1934.— “Growth and Development. xxiv. Basal metabolism, endogenous nitrogen, creatinine and neutral sulfur excretions as functions of the body weight.” Res. Bull. Mo. agric. Exp. Sta., 220. (W.L. 18682.)Google Scholar
Cameron, T. W. M., 1934.— “The Internal Parasites of Domestic Animals.” A. & C. Black: London.Google Scholar
Eggs, F. & Vanoli, G., 1935.— “Zur Methodik der Kreatin-Kreatininbistimmung im Harn.” Klin. Wschr., xiv (6), 204–205. (W.L. 11822.)CrossRefGoogle Scholar
Faust, E. C., 1939.— “Human Helminthology.” H. Kimpton: London.Google Scholar
Folin, O., 1914.— “On the determination of creatinine and creatine in urine.” J. biol. Chem.. xvii, 469. (W.L. 11063.)CrossRefGoogle Scholar
Hamil, J. M., 1906.— “On the mechanism of protection of intestinal worms and its bearing on the relation of entrokinase to trypsin.” J. Physiol., xxxiii, 479. (W.L. 11454.)CrossRefGoogle Scholar
Harned, B. K. & Nash, T. P., 1932.— “The protection of insulin by anti-proteases, and its absorption from the intestine.” J. biol. Chem., xcvii, 443. (W.L. 11063.)CrossRefGoogle Scholar
Hartman, E., Pierce, H., Simcox, W., Farniiam, W., Aitken, T. & Meservey, A., 1939.— “Blood chemistry in human trichinosis.” Amer. J. Hyg., xxix (2), 75–81. (W.L. 600a.)Google Scholar
Hartman, E., Pierce, H. & Foote, M., 1940.— “Blood chemistry findings in early trichinosis in dogs.” Amer. J.Hyg., xxxi (3), 74–75. (W.L. 600a.)Google Scholar
Jolliffe, N. & Smith, H. W., 1931.— “The excretion of urine in the dog. I. The urea and creatinine clearances in a mixed diet.” Amer. J. Physiol., xcviii, 572–577. (W.L. 613.)CrossRefGoogle Scholar
Jolliffe, N. & Smith, H. W., 1931.— “The excretion of urine in the dog. II. Urea and creatinine clearance on a cracker meal diet.” Amer. J. Physiol., xcix, 101–107. (W.L. 613.)CrossRefGoogle Scholar
Krebs, H. A., 1936.— “Metabolism of amino acids and related substances.” Ann. Rev. Biochem.. v, 247–270. (W.L. 1513.)CrossRefGoogle Scholar
Mann, F. C., 1927.— “The effects of complete and partial removal of the liver.” Medicine, Baltimore, vi, 419. (W.L. 13122a.)CrossRefGoogle Scholar
Markowicz, W. & Bock, D., 1931.— “Über Kreatin- and Kreatininausscheidung bei der Trichinose.” Z. ges. exp. Med., lxxix, 301–310. (W.L. 23422.)CrossRefGoogle Scholar
Peters, J. P. & Van Slyke, D. D., 1931.— “Quantitative Clinical Chemistry. Volume I. Interpretations.” Balliére, Tindall & Cox: London.Google Scholar
Schneller, H., 1935.— “Physiologische Bedeutung des Ammoniaks in Organism der Wirbeltiere.” Ergebn. Physiol., xxxvii, 492–529. (W.L. 7962.)CrossRefGoogle Scholar
Smith, H. W., 1937.— “The Physiology of the Kidney.” Oxford University Press: London.Google Scholar
Stewart, J., 1932.— “The effects of nematode infestations on the metabolism of the host. Part I. Metabolism experiments.” Rep. Inst. Anitm. Path. Univ. Camb., iii, 58–76. (W.L. 18252b.)Google Scholar
Stewart, J., 1932a.— “The effects of nematode infestations on the metabolism of the host. Part II. The isolation of a substance capable of inhibiting enzyme action.” Rep. Inst. Anim. Path. Univ. Camb., iii, 77–86. (W.L. 18252b.)Google Scholar
Van Slyke, D. D. & Cullen, G. E., 1916.— “The determination of urea by the urease method.” J. biol. Chem., xxiiv, 117. (W.L. 11063.)CrossRefGoogle Scholar