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Local and systemic antibody responses in gerbils following vaccination with irradiated or non-irradiated Trichostrongylus colubriformis larvae

Published online by Cambridge University Press:  05 June 2009

J. M. Maclean
Affiliation:
University of Glasgow Veterinary School, Glasgow, Scotland.
M. Abebe
Affiliation:
Institute of Pathobiology, Addis Ababa University, Ethiopia.
H. Wedrychowicz
Affiliation:
Department of Parasitology, Zoological Institute, University of Warszawa, Warsaw, Poland.
P. H. Holmes
Affiliation:
University of Glasgow Veterinary School, Glasgow, Scotland.

Abstract

Groups of 10 Mongolian gerbils. Meriones unguiculatus, were vaccinated with 1,500 gamma-irradiated Trichostrongylus colubriformis infective larvae (L3) or with non-irradiated larvae. 25 days later five gerbils from each group were necropised and the remaining gerbils challenged with 1,500 non-irradiated T. colubriformis infective larvae. Systemic, local intestinal and coproantibody levels were compared in each group of gerbils 25 days after vaccination and 26 days after challenge. Strong local intestinal and faecal antibody responses were detected. Coproantibodies reflected antibody levels in the intestinal contents and in mucosal extracts. The results gave further support to the view that coproantibody measurements provide a sensitive index of immunity at mucosal surfaces to intestinal parasites.

Type
Research Papers
Copyright
Copyright © Cambridge University Press 1986

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