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Immunity to Trichinella spiralis VI: The specificity of the immune response stimulated by the intestinal stage

Published online by Cambridge University Press:  05 June 2009

E. R. James  and
D. A. Denham
E. R. James
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London, London WCIE 7HT
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London, London WCIE 7HT
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Abstract

Mice were immunized to the intestinal stage of T. spiralis by using infections terminated with methyridine before production of newborn larvae had commenced. The muscle larvae which encysted following a normal complete challenge infection were reduced by 87 and 95% in immunized mice. No statistically significant reduction in a challenge infection of intravenously injected parenteral larvae was produced (8% and 15% actual reduction). Previous work has shown that adult worms in a challenge infection are stunted and expelled earlier as well as haying a reduced fecundity; it is concluded that the immunity generated by the intestinal stage is largely specific in its action to that phase in a challenge infection.

Type
Research Article
Information
Journal of Helminthology , Volume 49 , Issue 1 , March 1975 , pp. 43 - 47
Copyright
Copyright © Cambridge University Press 1975

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References

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