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Hippocampal sclerosis induced in mice by a Taenia crassiceps metacestode factor

Published online by Cambridge University Press:  23 August 2018

N. Zepeda ,
N. Copitin ,
J.L. Chávez ,
F. García ,
F. Jaimes-Miranda ,
R. Rincón-Heredia ,
R. Paredes ,
S. Solano ,
A.M. Fernández  and
J.L. Molinari Open the ORCID record for J.L. Molinari [Opens in a new window]
N. Zepeda
Affiliation:
Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
N. Copitin
Affiliation:
Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
J.L. Chávez
Affiliation:
Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
F. García
Affiliation:
Unidad de Imagenología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
F. Jaimes-Miranda
Affiliation:
Unidad de Imagenología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
R. Rincón-Heredia
Affiliation:
Unidad de Imagenología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
R. Paredes
Affiliation:
Unidad de Imagenología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
S. Solano
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510
A.M. Fernández
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510
J.L. Molinari*
Affiliation:
Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242
*
Author for correspondence: J.L. Molinari, E-mail: jmolinar@ifc.unam.mx
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Abstract

An experimental Taenia crassiceps mouse model was used to assess the role of Taenia solium metacestode factor (Fac) in human neurocysticercosis. Intraperitoneal infection with T. crassiceps metacestodes or subcutaneous inoculation with a T. crassiceps metacestode factor (Fac) produced significant impairment of performance (learning) in the Barnes maze and induced bilateral hippocampal sclerosis in mice. Several staining techniques revealed important cell dispersion, extensive apoptosis and cell loss in the dentate gyrus, hilus and CA1-CA3 regions of both hippocampi, as well as intense deterioration of the adjacent cortex. An outstanding disruption of its histoarchitecture in the surrounding tissue of all these regions and apoptosis of the endothelial cells were also observed.

Keywords

apoptosisBarnes mazehippocampal sclerosis, metacestode factor (Fac)mouse modelneurocysticercosisTaenia crassicepsTaenia solium
Type
Research Paper
Information
Journal of Helminthology , Volume 93 , Issue 6 , November 2019 , pp. 690 - 696
Copyright
Copyright © Cambridge University Press 2018 

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