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Failure to infect laboratory rodent hosts with human isolates of Rodentolepis (= Hymenolepis) nana

Published online by Cambridge University Press:  12 April 2024

M.G. Macnish ,
U.M. Morgan ,
J.M. Behnke  and
R.C.A. Thompson
M.G. Macnish
Affiliation:
WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
U.M. Morgan
Affiliation:
WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
J.M. Behnke
Affiliation:
School of Life and Environmental Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
R.C.A. Thompson*
Affiliation:
WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
*
*Author for correspondence Fax: (61 8) 9310 4144 Email: andrew-t@numbat.murdoch.edu.au
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Abstract

Confusion exists over the species status and host-specificity of the tapeworm Rodentolepis (= Hymenolepis) nana. It has been described as one species, R. nana, found in both humans and rodents. Others have identified a subspecies; R. nana var. fraterna, describing it as morphologically identical to the human form but only found in rodents. The species present in Australian communities has never been identified with certainty. Fifty one human isolates of Rodentolepis (= Hymenolepis) nana were orally inoculated into Swiss Q, BALB/c, A/J, CBA/CAH and nude (hypothymic) BALB/c mice, Fischer 344 and Wistar rats and specific pathogen free (SPF) hamsters. Twenty four human isolates of R. nana were cross-tested in flour beetles, Tribolium confusum. No adult worms were obtained from mice, rats or hamsters, even when immunosuppressed with cortisone acetate. Only one of the 24 samples developed to the cysticercoid stage in T. confusum; however, when inoculated into laboratory mice the cysticercoids failed to develop into adult worms. The large sample size used in this study, and the range of techniques employed for extraction and preparation of eggs provide a comprehensive test of the hypothesis that the human strain of R. nana is essentially non-infective to rodents.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 1 , March 2002 , pp. 37 - 43
Copyright
Copyright © Cambridge University Press 2002

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