Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-06-05T02:49:51.562Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental infections with Nematodirus spathiger in rabbits

Published online by Cambridge University Press:  05 June 2009

H. Hoste  and
G. Fort
H. Hoste
Affiliation:
C. R. INRA Tours-Nouzilly, Station de Pathologie Aviaire et de Parasitologie, F-37380 Nouzilly, France
G. Fort
Affiliation:
C. R. INRA Tours-Nouzilly, Station de Pathologie Aviaire et de Parasitologie, F-37380 Nouzilly, France
Get access Rights & Permissions [Opens in a new window]

Abstract

The feasibility of infecting laboratory rabbits experimentally with the ovine nematode Nematodirus spathiger was examined. Eight-week-old rabbits were dosed either with 5000 or with 17 000 third-stage larvae and killed on days 10, 21 or 42 post-infection. With the lower dose, 20 to 40% of the inoculum were recovered at necropsy. Similar values were recovered at necropsy. Similar values were observed with the 17 000 dose on days 10 and 21 post-infection, but on day 42 the worm population was residual (0·6%). With both dose levels, during the course of infection, the worm populations were mainly composed of fourth-stage larvae and worm egg excretion was low. N. spathiger mainly inhabited the proximal jejunum. The results were compared with N. spathiger infection in sheep to assess the usefulness of the rabbit as an experimental model for Nematodirus infection.

Keywords

Nematodirus spathigerrabbitexperimental modelNematoda
Type
Research Article
Information
Journal of Helminthology , Volume 66 , Issue 3 , September 1992 , pp. 227 - 230
Copyright
Copyright © Cambridge University Press 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bezubik, B., Wedrychowicz, H. & Wojciechowska, A. (1988) Trichostrongylus colubriformis in rabbits: some quantitative aspects and pathogenesis of single and multiple infections. Acta Parasitologica Polonica, 33, 131–142.Google Scholar
Boag, B. (1972) Helminth parasites of the wild rabbit Oryctolagus cuniculus in North East England. Journal of Helminthology, 46, 73–79.CrossRefGoogle ScholarPubMed
Donald, A. D., Dineen, J. K., Turner, J. H. & Wagland, B. M. (1964) The dynamics of the host-parasite relationship: I. Nematodirus spathiger infection in sheep. Parasitology, 54, 527–544.CrossRefGoogle ScholarPubMed
Gallie, G. J. (1972) Development of the parasitic stages of Nematodirus battus in the laboratory rabbit, Parasitology, 64, 293–304.CrossRefGoogle ScholarPubMed
Herlich, H. (1976) The rabbit T. axei—T. colubriformis system as a preliminary screen for testing potential anthelmintics. Veterinary Parasitology. 2, 377–383.CrossRefGoogle Scholar
Hopkins, P. G. (1975) The experimental establishment of populations of Nematodirus battus and Trichostrongylus colubriformis, nematode parasites of the intestine of sheep in laboratory rabbits; dose dependent features of the establishment and use of such populations in the study of resistance to anthelmintics. PhD University of Edinburgh. 216 pp.Google Scholar
Hoste, H., Kerboeuf, D. & Parodi, A. L. (1988) Trichostrongylus colubriformis: Effects on villi and crypts along the whole small intestine in infected rabbits. Experimental Parasitology, 67, 39–46.CrossRefGoogle ScholarPubMed
Knight, R. A. (1977) Effect of dexamethasone on experimental infections of Trichostrongylus affinis and Nematodirus spathiger in rabbits. Journal of Parasitology, 63, 957–958.CrossRefGoogle ScholarPubMed
McLean, J. M., Lewis, D. & Holmes, P. H. (1987) The pathogenesis of benzimidazole resistant and benzimidazole susceptible strains of Trichostrongylus colubriformis in the mongolian gerbil (Meriones unguiculatus). Journal of Helminthology, 61, 179–189.CrossRefGoogle Scholar
Mapes, C. J. & Coop, R. L. (1972) The development of single infections of Nematodirus battus in lambs. Parasitology, 64, 197–216.CrossRefGoogle ScholarPubMed
Raynaud, J. P. (1970) Etude de I'efficacite d'une technique de coproscopie quantitative pour le diagnostic de routine et le controle des infestations parasitaires des bovins, ovins, équins et porcins. Annales de Parasitologie Humaine et Comparée, 45, 321–342.CrossRefGoogle Scholar
Rothwell, T. L. W. & Dineen, J. K. (1972) Cellular reactions in guinea-pigs following primary and challenge infection with Trichostrongylus colubriformis with special reference to the roles played by eosinophils and basophils in rejection of the parasite. Immunology, 22, 733–745.Google Scholar
Sommerville, R. I. (1963) Distribution of some parasitic nematodes in the alimentary tract of sheep, cattle and rabbits, Journal of Parasitology, 49, 593–599.CrossRefGoogle ScholarPubMed