Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-06-23T08:46:37.493Z Has data issue: false hasContentIssue false
  • English
  • Français

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

Published online by Cambridge University Press:  12 April 2024

J.-F. Magnaval ,
J.-H. Faufingue ,
B. Morassin  and
R. Fabre
J.-F. Magnaval*
Affiliation:
Department of Parasitology, CH Rangueil, University Hospitals, 31059 Toulouse 9, France
J.-H. Faufingue
Affiliation:
Department of Parasitology, CH Rangueil, University Hospitals, 31059 Toulouse 9, France
B. Morassin
Affiliation:
Department of Parasitology, CH Rangueil, University Hospitals, 31059 Toulouse 9, France
R. Fabre
Affiliation:
Department of Parasitology, CH Rangueil, University Hospitals, 31059 Toulouse 9, France
*
*Corresponding author: Fax: 33 5 61 14 59 72, Email: magnaval@cict.fr
Get access Rights & Permissions [Opens in a new window]

Abstract

Among 67 French patients presenting a toxocaral infection, various demographic, environmental, clinical and laboratory parameters (blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE, specific IgE against common inhalant allergens, specific IgE and IgG4 against Toxocara excretory-secretory antigens) were investigated. Correlation studies and logistic regression analyses were conducted, testing elevated levels of ECP, specific anti-Toxocara IgE or IgG4 as outcome variables An elevated ECP level was significantly associated with both cough and rhinitis, a high level of specific anti-Toxocara IgE with itchy rashes and possible atopic status, and an increase of specific anti-Toxocara IgG4 with rural residence.

Type
Research Article
Information
Journal of Helminthology , Volume 80 , Issue 4 , December 2006 , pp. 417 - 423
Copyright
Copyright © Cambridge University Press 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aalberse, R. (2000) Specific IgE and IgG responses in atopic versus non-atopic subjects. American Journal of Respiratory and Critical Care Medicine 162, 5124–5127.CrossRefGoogle Scholar
Addiss, D.G., Dimock, K.A., Eberhard, M.L. & Lammie, P.J. (1995) Clinical, parasitologic, and immunologic observations of patients with hydrocele and elephantiasis in an area with endemic lymphatic filariasis. Journal of Infectious Diseases 171, 755–758.CrossRefGoogle Scholar
Beaver, P.C. (1956) Larva migrans. Experimental Parasitology 5, 587–621.CrossRefGoogle ScholarPubMed
Bowman, D.D., Mika-Grieve, M. & Grieve, R.B. (1987) Circulating excretory antigens levels and specific antibody responses in mice infected with Toxocara canis. American Journal of Tropical Medicine and Hygiene 36, 75–82.CrossRefGoogle ScholarPubMed
Brinkman, V. & Heusser, C.H. (1993) T-cell dependent differentiation phenomenon of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited IgE expression of IgE precursors. Cellular Immunology 152, 323–332.CrossRefGoogle Scholar
Buijs, J., Borsboom, G., van Gemund, J.J., Hazebroek, A., van Dongen, P.A., van Knapen, F. & Neijens, H.J. (1994) Toxocara seroprevalence in 5-year-old elementary schoolchildren: relation with allergic asthma. American Journal of Epidemiology 140, 839–847.CrossRefGoogle ScholarPubMed
Capron, M. & Capron, A. (1992) Effector functions of eosinophils in schistosomiasis. Memorias do Instituto Oswaldo Cruz 87 (Suppl 4), 167–170.CrossRefGoogle ScholarPubMed
Daeki, A.O., Craig, P.S. & Shambesh, M.K. (2000) IgG-subclass antibody responses and the natural history of hepatic cystic echinococcosis in asymptomatic patients. Annals of Tropical Medicine and Parasitology 94, 319–328.CrossRefGoogle ScholarPubMed
De Savigny, D.H. (1975) In vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara ES antigens for use in serodiagnostic tests for visceral larva migrans. Journal of Parasitology 61, 781–782.CrossRefGoogle Scholar
Fujisawa, T., Terada, A., Atsuta, J., Iguchi, K., Kamiya, H. & Sakurai, M. (1998) Clinical utility of serum levels of eosinophil cationic protein (ECP) for monitoring and predicting clinical course in childhood asthma. Clinical and Experimental Allergy 28, 19–25.CrossRefGoogle ScholarPubMed
Genchi, C., Falagiani, P., Riva, G., Tinelli, M., Brunello, F., Boero, M. & Almaviva, M. (1988) IgE and IgG antibodies in Toxocara canis infection. A clinical evaluation. Annals of Allergy 61, 43–46.Google ScholarPubMed
Glickman, L.T., Magnaval, J.-F., Domanski, L.M., Shofer, F.S., Lauria, S.S., Gottstein, B. & Brochier, B. (1987) Visceral larva migrans in French adults. A new disease syndrome? American Journal of Epidemiology 125, 1019–1033.CrossRefGoogle ScholarPubMed
Hill, I.R., Denham, D.A. & Scholtz, C.L. (1985) Toxocara canis larvae in the brain of a British child. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 351–354.CrossRefGoogle ScholarPubMed
Kaplan, K.J., Goodman, Z.D. & Ishak, K.G. (2001) Eosinophilic granuloma of the liver: a characteristic lesion with relationship to visceral larva migrans. American Journal of Surgical Pathology 25, 1316–1321.CrossRefGoogle ScholarPubMed
Kayes, S.G. (1997) Human toxocariasis and the visceral larva migrans syndrome: correlative immunopathology. Chemical Immunology 66, 99–124.Google ScholarPubMed
Kayes, S.G. & Oaks, J.A. (1978) Development of the granulomatous response in murine toxocariasis. Initial events. American Journal of Pathology 93, 277–294.Google ScholarPubMed
Kurniawan, A., Yazdanbakhsh, M., van Ree, R., Aalberse, R., Selkirk, M.E., Partono, F. & Maizels, R.M. (1993) Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. Journal of Immunology 150, 3941–3950.CrossRefGoogle ScholarPubMed
Li, Y., Sleigh, A.C., Ross, A.G., Li, Y., Zhang, X., Williams, G.M., Yu, X., Tanner, M. & McManus, D.P. (2001) Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 441–448.CrossRefGoogle Scholar
Magnaval, J.-F. (1995) Comparative efficacy of diethy lcarbamazine and mebendazole for the treatment of human toxocariasis. Parasitology 110, 529–533.CrossRefGoogle Scholar
Magnaval, J.-F. & Baixench, M.-T. (1993) Toxocariasis in Région Midi-Pyrénées, France. pp. 83–87 in Lewis, J.W. & Maizels, R.D. (Eds) Toxocara and toxocariasis. Clinical, epidemiological, and molecular perspectives. London, Institute of Biology and British Society for Parasitology.Google Scholar
Magnaval, J.-F., Fabre, R., Maurieres, P., Charlet, J.-P. & De Larrard, B. (1991) Application of the western-blotting procedure for the immunodiagnosis of human toxocariasis. Parasitology Research 77, 697–702.CrossRefGoogle ScholarPubMed
Magnaval, J.-F., Fabre, R., Maurieres, P., Charlet, J.-P. & De Larrard, B. (1992) Evaluation of an immunoenzymatic assay detecting specific anti-Toxocara immunoglobulin E for diagnosis and post-treatment follow-up of human toxocariasis. Journal of Clinical Microbiology 30, 2269–2274.CrossRefGoogle Scholar
Magnaval, J.-F., Berry, A., Fabre, R. & Morassin, B. (2001a) Eosinophil cationic protein as a possible marker of active human Toxocara infection. Allergy 56, 1096–1099.CrossRefGoogle ScholarPubMed
Magnaval, J.-F., Glickman, L.T., Dorchies, P. & Morassin, B. (2001b) Highlights of human toxocariasis. Korean Journal of Parasitology 39, 1–11.CrossRefGoogle ScholarPubMed
Maizels, R.M. & Page, A.P. (1990) Surface associated glycoproteins from Toxocara canis larval parasites. Acta Tropica 47, 355–364.CrossRefGoogle ScholarPubMed
Meeusen, E.N. (1999) Immunology of helminth infections, with special reference to immunopathology. Veterinary Parasitology 84, 259–273.CrossRefGoogle ScholarPubMed
Moffatt, M.F. & Cookson, W.O. (1998) Gene identifi- cation in asthma and allergy. International Archives of Allergy and Immunology 116, 247–252.CrossRefGoogle Scholar
Motojima, S., Tateishi, K., Koseki, T., Makino, S. & Fukuda, T. (1997) Serum levels of eosinophil cationic protein and IL-5 in patients with asthma without systemic corticosteroids. International Archives of Allergy and Immunology 114, 55–59.CrossRefGoogle ScholarPubMed
Nagakura, K., Kanno, S., Tachibana, H., Kaneda, Y., Ohkido, M., Kondo, K. & Inoue, H. (1990) Serologic differentiation between Toxocara canis and Toxocara cati. Journal of Infectious Diseases 162, 1418–1419.CrossRefGoogle ScholarPubMed
Noordin, R., Smith, H.V., Mohamad, S., Maizels, R.M. & Fon, M.F. (2005) Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis. Acta Tropica 93, 57–62.CrossRefGoogle ScholarPubMed
Nutten, S., Trottein, F., Gounni, A.S., Papin, J.P., Capron, A. & Capron, M. (1997) From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function. Memórias do Instituto Oswaldo Cruz 92 (Suppl 2), 9–14.CrossRefGoogle ScholarPubMed
Obwaller, A., Jensen-Jarolim, E., Auer, H., Huber, A., Kraft, D. & Aspock, H. (1998) Toxocara infestations in humans: symptomatic course of toxocarosis correlates significantly with levels of IgE/anti-IgE immune complexes. Parasite Immunology 20, 311–317.CrossRefGoogle ScholarPubMed
Parsons, J.C. & Grieve, R.B. (1990) Effect of egg dosage and host genotype on liver trapping in murine larval toxocariasis. Journal of Parasitology 76, 53–58.CrossRefGoogle ScholarPubMed
Simmons, A., Leaverton, P. & Elbert, G. (1974) Normal laboratory values for differential white cell counts established by manual and automated cytochemical methods (Hemalog De). Journal of Clinical Pathology 27, 55–58.CrossRefGoogle Scholar
Simonsen, P.E. & Meyrowitsch, D.W. (1998) Bancroftian filariasis in Tanzania: specific antibody responses in relation to long-term observations on microfilaremia. American Journal of Tropical Medicine and Hygiene 59, 667–672.CrossRefGoogle ScholarPubMed
Smith, H.V., Kusel, J.R. & Girdwood, R.W. (1983) The production of human A and B blood group like substances by in vitro maintained second stage Toxocara canis larvae: their presence on the outer larval surfaces and in their excretions/secretions. Clinical and Experimental Immunology 54, 625–633.Google Scholar
Soulsby, E.J.L. (1987) Larva migrans in perspective. pp. 37–48 in Geerts, S., Kumar, V. & Brandt, J. (Eds) Helminth zoonoses., Dordrecht, Martinus Nijhoff.Google Scholar
Sugane, K., Kusama, Y., Takamoto, M., Tominaga, A. & Takatsu, K. (1996) Eosinophilia, IL-5 level and recovery of larvae in IL-5 transgenic mice infected with Toxocara canis. Journal of Helminthology 70, 153–158.CrossRefGoogle ScholarPubMed
Taylor, M., Keane, C., O'Connor, P., Mulvihill, E. & Holland, C. (1988) The expanded spectrum of toxocaral disease. Lancet i, 692–695.CrossRefGoogle Scholar
Tischendorf, F.W., Brattig, N.W., Lintzel, M., Buttner, D.W., Burchard, G.D., Bork, K. & Muller, M. (2000) Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis. Tropical Medicine and International Health 5, 898–905.CrossRefGoogle ScholarPubMed
Tomassini, M., Magrini, L., De Petrillo, G., Adriani, E., Bonini, S., Balsano, F. & Bonini, S. (1996) Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure. Journal of Allergy and Clinical Immunology 97, 1350–1355.CrossRefGoogle ScholarPubMed
Werner, J.C., Ross, R.D., Green, W.R. & Watts, J. C. (1999) Pars plana vitrectomy and subretinal surgery for ocular toxocariasis. Archives of Ophthalmology 117, 532–534.CrossRefGoogle ScholarPubMed
Yahiro, S., Cain, G. & Butler, J.E. (1998) Identification, characterization and expression of Toxocara canis nematode polyprotein allergen TBA-1. Parasite Immunology 20, 351–357.CrossRefGoogle ScholarPubMed