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Effect of mercury on the immune response and mean intensity of Ascaris suum infection in guinea pigs

Published online by Cambridge University Press:  05 June 2009

Z. Borošková ,
J. Šoltys  and
M. Benková
Z. Borošková
Affiliation:
Parasitological Institute SAS, Hlinkova 3, Košice, Slovak Republic
J. Šoltys
Affiliation:
Parasitological Institute SAS, Hlinkova 3, Košice, Slovak Republic
M. Benková
Affiliation:
Parasitological Institute SAS, Hlinkova 3, Košice, Slovak Republic
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Abstract

The subchronic effect of mercury on selected immunological parameters was studied in guinea pigs with experimental Ascaris suum infection. HgCl2 given for 28 days reduced significantly T- and B-cell populations in the lymphoid organs and the phagocytic ability of peritoneal macrophages. The subsequent infection of HgCl2-intoxicated animals elevated the studied immunological parameters, but in comparison with infected non-intoxicated guinea pigs they remained significantly suppressed. The mercury compound in infection stressed animals caused a slight alteration of the complement CH50 and AH50 activity. The specific circulating antibody level in infected and HgCl2 treated animals rose a little by day 12 p.i. and then again decreased significantly, compared with untreated guinea pigs. The mean intensity of infection with migrating Ascaris larvae in HgC12 -treated animals increased by 15%, compared with controls.

Type
Research Papers
Information
Journal of Helminthology , Volume 69 , Issue 3 , September 1995 , pp. 187 - 194
Copyright
Copyright © Cambridge University Press 1995

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