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Effect of Irradiation on the Infective Stage Larvae of the Nematode, Oesophagostomum columbianum and their Use as a Vaccine

Published online by Cambridge University Press:  05 June 2009

D. N. Dhar  and
Kunwar Suresh Singh
D. N. Dhar
Affiliation:
Post-Graduate College of Animal Sciences, Indian Veterinary Research Institute, Izatnagar, U.P.
Kunwar Suresh Singh
Affiliation:
Post-Graduate College of Animal Sciences, Indian Veterinary Research Institute, Izatnagar, U.P.
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Extract

The effect of irradiation on the survival, behaviour and immunogenicity of the infective (3rd stage) larvae of O. columbianum was studied. The findings reported are:

1. Irradiation with up to 160,000 r does not significantly alter the survival of the larvae when stored at 4°C and at room temperature (26–32°C) for a period of 42 days.

2. Irradiation at 15.000 r to 40,000 r results in progressively fewer adults developing but more nodules being formed in the intestinal wall. Irradiation at 80,000 r results in the larvae failing to develop and establish in the host.

Type
Research Article
Information
Journal of Helminthology , Volume 44 , Issue 1 , March 1970 , pp. 11 - 26
Copyright
Copyright © Cambridge University Press 1970

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